Reduced platelet tritium-labeled imipramine binding sites in women with premenstrual syndrome

John F. Steege, Anna L. Stout, David L. Knight, Charles B. Nemeroff

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

Objective: We studied the possible role of serotonergic systems in the cause of premenstrual affective symptoms. Study design: The binding of tritium-labeled imipramine to platelets is thought to parallel central nervous system binding and to indicate serotonergic activity. We measured platelet tritium-labeled imipramine binding sites in the follicular and luteal phases in 12 controls and in 9 women with well-documented late luteal phase dysphoric disorder. In statistical analyses we used repeated measures analysis of variance, with Student-Newman-Keuls and Duncan's one-tailed t tests, and Pearson's r. Results: The values of subjects with late luteal phase dysphoric disorder were lower than those of controls (F [1,39] = 5.13, p = 0.03). Both follicular and luteal phase levels were lower in subjects with late luteal phase dysphoric disorder but reached statistical significance only in the follicular phase. Conclusion: Lower platelet tritium-labeled imipramine binding in women with late luteal phase dysphoric disorder supports the hypothesis that alteration of central serotonergic systems may contribute to premenstrual dysphoric symptoms.

Original languageEnglish (US)
Pages (from-to)168-172
Number of pages5
JournalAmerican journal of obstetrics and gynecology
Volume167
Issue number1
DOIs
StatePublished - Jan 1 1992
Externally publishedYes

Keywords

  • depression
  • late luteal phase dysphoric disorder
  • premenstrual syndrome
  • tritium-labeled imiprimine binding

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

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