Reduced platelet tritium-labeled imipramine binding sites in women with premenstrual syndrome

J. F. Steege, A. L. Stout, D. L. Knight, Charles Nemeroff

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Objective: We studied the possible role of serotonergic systems in the cause of premenstrual affective symptoms. Study design: The binding of tritium-labeled imipramine to platelets is thought to parallel central nervous system binding and to indicate serotonergic activity. We measured platelet tritium-labeled imipramine binding sites in the follicular and luteal phases in 12 controls and in 9 women with well-documented late luteal phase dysphoric disorder. In statistical analyses we used repeated measures analysis of variance, with Student-Newman-Keuls and Duncan's one-tailed t tests, and Pearson's r. Results: The values of subjects with late luteal phase dysphoric disorder were lower than those of controls (F [1,39] = 5.13, p = 0.03). Both follicular and luteal phase levels were lower in subjects with late luteal phase dysphoric disorder but reached statistical significance only in the follicular phase. Conclusion: Lower platelet tritium-labeled imipramine binding in women with late luteal phase dysphoric disorder supports the hypothesis that alteration of central serotonergic systems may contribute to premenstrual dysphoric symptoms.

Original languageEnglish
Pages (from-to)168-172
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Volume167
Issue number1
StatePublished - Jan 1 1992
Externally publishedYes

Fingerprint

Premenstrual Syndrome
Tritium
Imipramine
Luteal Phase
Blood Platelets
Binding Sites
Follicular Phase
Affective Symptoms
Analysis of Variance
Central Nervous System
Students

Keywords

  • depression
  • late luteal phase dysphoric disorder
  • premenstrual syndrome
  • tritium-labeled imiprimine binding

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Reduced platelet tritium-labeled imipramine binding sites in women with premenstrual syndrome. / Steege, J. F.; Stout, A. L.; Knight, D. L.; Nemeroff, Charles.

In: American Journal of Obstetrics and Gynecology, Vol. 167, No. 1, 01.01.1992, p. 168-172.

Research output: Contribution to journalArticle

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