Reduced hippocampal volume and verbal memory performance associated with interleukin-6 and tumor necrosis factor-alpha levels in chemotherapy-treated breast cancer survivors

Shelli Kesler, Michelle Janelsins, Della Koovakkattu, Oxana Palesh, Karen Mustian, Gary Morrow, Firdaus Dhabhar

Research output: Contribution to journalArticle

133 Citations (Scopus)

Abstract

Many survivors of breast cancer show significant cognitive impairments, including memory deficits. Inflammation induced by chemotherapy may contribute to hippocampal changes that underlie these deficits. In this cross-sectional study, we measured bilateral hippocampal volumes from high-resolution magnetic resonance images in 42 chemotherapy-treated breast cancer survivors and 35 healthy female controls. Patients with breast cancer were, on average, 4.8. ±. 3.4. years off-therapy. In a subset of these participants (20 breast cancer, 23 controls), we quantified serum cytokine levels. Left hippocampal volumes and memory performance were significantly reduced and interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNFα) concentrations were significantly elevated in the breast cancer group compared to controls. In the breast cancer group, lower left hippocampal volume was associated with higher levels of TNFα and lower levels of IL-6 with a significant interaction between these two cytokines suggesting a potential modulatory effect of IL-6 on TNFα. Verbal memory performance was associated with cytokine levels and left hippocampal volume in both groups. These findings provide evidence of altered hippocampal volume and verbal memory difficulties following breast cancer chemotherapy that may be mediated by TNFα and IL-6.

Original languageEnglish (US)
JournalBrain, Behavior, and Immunity
Volume30
Issue numberSUPPL.
DOIs
StatePublished - Mar 15 2013
Externally publishedYes

Fingerprint

Survivors
Interleukin-6
Tumor Necrosis Factor-alpha
Breast Neoplasms
Drug Therapy
Cytokines
Memory Disorders
Magnetic Resonance Spectroscopy
Cross-Sectional Studies
Inflammation
Serum

Keywords

  • Breast cancer
  • Chemotherapy
  • Hippocampus
  • Interleukin-6
  • Memory
  • MRI
  • Tumor necrosis factor-alpha

ASJC Scopus subject areas

  • Immunology
  • Endocrine and Autonomic Systems
  • Behavioral Neuroscience

Cite this

Reduced hippocampal volume and verbal memory performance associated with interleukin-6 and tumor necrosis factor-alpha levels in chemotherapy-treated breast cancer survivors. / Kesler, Shelli; Janelsins, Michelle; Koovakkattu, Della; Palesh, Oxana; Mustian, Karen; Morrow, Gary; Dhabhar, Firdaus.

In: Brain, Behavior, and Immunity, Vol. 30, No. SUPPL., 15.03.2013.

Research output: Contribution to journalArticle

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