Abstract
Dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis is common in patients with major depression. A recent study demonstrates that reduced expression of the glucocorticoid receptor in mice causes depression-like behaviors and HPA axis dysfunction following stressor exposure. This model offers a novel system for the study of the pathophysiology that underlies depression-like behaviors. It also adds to the growing evidence that implicates glucocorticoid receptor dysfunction in depression.
Original language | English (US) |
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Pages (from-to) | 124-125 |
Number of pages | 2 |
Journal | Trends in Endocrinology and Metabolism |
Volume | 17 |
Issue number | 4 |
DOIs | |
State | Published - May 2006 |
Externally published | Yes |
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Endocrinology