Reduced glucocorticoid receptors: consequence or cause of depression?

Gretchen N. Neigh; Charles B. Nemeroff

doi:10.1016/j.tem.2006.03.002

Reduced glucocorticoid receptors: consequence or cause of depression?

Gretchen N. Neigh, Charles B. Nemeroff

Psychiatry & Behavioral Sciences

Research output: Contribution to journal › Short survey › peer-review

37 Scopus citations

Abstract

Dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis is common in patients with major depression. A recent study demonstrates that reduced expression of the glucocorticoid receptor in mice causes depression-like behaviors and HPA axis dysfunction following stressor exposure. This model offers a novel system for the study of the pathophysiology that underlies depression-like behaviors. It also adds to the growing evidence that implicates glucocorticoid receptor dysfunction in depression.

Original language	English (US)
Pages (from-to)	124-125
Number of pages	2
Journal	Trends in Endocrinology and Metabolism
Volume	17
Issue number	4
DOIs	https://doi.org/10.1016/j.tem.2006.03.002
State	Published - May 2006

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

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title = "Reduced glucocorticoid receptors: consequence or cause of depression?",

abstract = "Dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis is common in patients with major depression. A recent study demonstrates that reduced expression of the glucocorticoid receptor in mice causes depression-like behaviors and HPA axis dysfunction following stressor exposure. This model offers a novel system for the study of the pathophysiology that underlies depression-like behaviors. It also adds to the growing evidence that implicates glucocorticoid receptor dysfunction in depression.",

author = "Neigh, {Gretchen N.} and Nemeroff, {Charles B.}",

note = "Funding Information: This work was funded by the National Institute of Health (NIH) MH-42088, NIH MH-52899, and a NIH Institutional Research and Academic Career Development grant K12GM00680-05.",

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AU - Nemeroff, Charles B.

N1 - Funding Information: This work was funded by the National Institute of Health (NIH) MH-42088, NIH MH-52899, and a NIH Institutional Research and Academic Career Development grant K12GM00680-05.

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N2 - Dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis is common in patients with major depression. A recent study demonstrates that reduced expression of the glucocorticoid receptor in mice causes depression-like behaviors and HPA axis dysfunction following stressor exposure. This model offers a novel system for the study of the pathophysiology that underlies depression-like behaviors. It also adds to the growing evidence that implicates glucocorticoid receptor dysfunction in depression.

AB - Dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis is common in patients with major depression. A recent study demonstrates that reduced expression of the glucocorticoid receptor in mice causes depression-like behaviors and HPA axis dysfunction following stressor exposure. This model offers a novel system for the study of the pathophysiology that underlies depression-like behaviors. It also adds to the growing evidence that implicates glucocorticoid receptor dysfunction in depression.

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