Reduced glucocorticoid receptors: consequence or cause of depression?

Gretchen N. Neigh, Charles B. Nemeroff

Research output: Contribution to journalShort surveypeer-review

40 Scopus citations


Dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis is common in patients with major depression. A recent study demonstrates that reduced expression of the glucocorticoid receptor in mice causes depression-like behaviors and HPA axis dysfunction following stressor exposure. This model offers a novel system for the study of the pathophysiology that underlies depression-like behaviors. It also adds to the growing evidence that implicates glucocorticoid receptor dysfunction in depression.

Original languageEnglish (US)
Pages (from-to)124-125
Number of pages2
JournalTrends in Endocrinology and Metabolism
Issue number4
StatePublished - May 2006
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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