Reduced corticotropin releasing factor binding sites in the frontral cortex of suicide victims

Charles Nemeroff, M. J. Owens, G. Bissette, A. C. Andorn, M. Stanley

Research output: Contribution to journalArticle

488 Citations (Scopus)

Abstract

Previous studies have provided evidence that corticotropin releasing factor (CRF) is hypersecreted in patients with major depression. This CRF hypersecretion is believed to contribute at least in part to hyperactivity of the hypothalamic-pituitary-adrenalaxis in depressed patients. If CRF is chronically hypersecreted in depressed patients, then, due to down-regulation, a reduced number of CRF receptor binding sites should be present in patients with profound depressive disorder. To test this hypothesis, we measured the number and affinity of CRF binding sites in the frontal cortex of 26 suicide victims and 29 controls who died of a variety of causes. There was a marked (23%) reduction in the number of CRF binding sites in the frontal cortex of the suicide victims compared with the controls. These data are consistent with the hypothesis that CRF is hypersecreted in depression.

Original languageEnglish
Pages (from-to)577-579
Number of pages3
JournalArchives of General Psychiatry
Volume45
Issue number6
StatePublished - Jan 1 1988
Externally publishedYes

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Corticotropin-Releasing Hormone
Suicide
Binding Sites
Frontal Lobe
Depression
Corticotropin-Releasing Hormone Receptors
Depressive Disorder
Down-Regulation

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Reduced corticotropin releasing factor binding sites in the frontral cortex of suicide victims. / Nemeroff, Charles; Owens, M. J.; Bissette, G.; Andorn, A. C.; Stanley, M.

In: Archives of General Psychiatry, Vol. 45, No. 6, 01.01.1988, p. 577-579.

Research output: Contribution to journalArticle

Nemeroff, C, Owens, MJ, Bissette, G, Andorn, AC & Stanley, M 1988, 'Reduced corticotropin releasing factor binding sites in the frontral cortex of suicide victims', Archives of General Psychiatry, vol. 45, no. 6, pp. 577-579.
Nemeroff, Charles ; Owens, M. J. ; Bissette, G. ; Andorn, A. C. ; Stanley, M. / Reduced corticotropin releasing factor binding sites in the frontral cortex of suicide victims. In: Archives of General Psychiatry. 1988 ; Vol. 45, No. 6. pp. 577-579.
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