Abstract
Fourteen patients with spinocerebellar degeneration (SCD) were subjected to MRI and PET studies. The quantitative MRI data revealed significant cerebellar and pontine atrophy in the patients with olivopontocerebellar atrophy (OPCA), and cerebellar atrophy in the patients with late cerebellar cortical atrophy (LCCA). We failed to demonstrate significant differences in the pons between LCCA patients and normal controls. PET measurements revealed decreases in cerebral oxygen metabolic rate (CMRO2) in the cerebellar hemisphere and vermis in both groups of patients. The markedly decreased cerebral blood flow (CBF) and CMRO2 in the pons were found only in the patients with OPCA. PET data corrected for the tissue shrinkage on the basis of MRI morphometry indicated a net reduction in cerebellar CMRO2 and CBE The present study has demonstrated that a combination of functional and anatomical data offers further evidence in favour of the current acceptable classification of SCD based on clinicopathological grounds. Our data further suggest that the amount of atrophy in the cerebellum could not fully account for the decreased metabolic rates observed in PET studies.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 295-300 |
| Number of pages | 6 |
| Journal | Journal of Neurology |
| Volume | 241 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 1994 |
| Externally published | Yes |
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Keywords
- Cerebellar metabolism
- Late cerebellar cortical atrophy
- Magnetic resonance imaging
- Olivopontocerebellar atrophy
- Positron emission tomography
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
Cite this
Reduced cerebellar blood flow and oxygen metabolism in spinocerebellar degeneration : a combined PET and MRI study. / Sun, Xiaoyan; Tanaka, Makoto; Kondo, Susumu; Hirai, Shunsaku; Ishihara, Tomio.
In: Journal of Neurology, Vol. 241, No. 5, 05.1994, p. 295-300.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Reduced cerebellar blood flow and oxygen metabolism in spinocerebellar degeneration
T2 - a combined PET and MRI study
AU - Sun, Xiaoyan
AU - Tanaka, Makoto
AU - Kondo, Susumu
AU - Hirai, Shunsaku
AU - Ishihara, Tomio
PY - 1994/5
Y1 - 1994/5
N2 - Fourteen patients with spinocerebellar degeneration (SCD) were subjected to MRI and PET studies. The quantitative MRI data revealed significant cerebellar and pontine atrophy in the patients with olivopontocerebellar atrophy (OPCA), and cerebellar atrophy in the patients with late cerebellar cortical atrophy (LCCA). We failed to demonstrate significant differences in the pons between LCCA patients and normal controls. PET measurements revealed decreases in cerebral oxygen metabolic rate (CMRO2) in the cerebellar hemisphere and vermis in both groups of patients. The markedly decreased cerebral blood flow (CBF) and CMRO2 in the pons were found only in the patients with OPCA. PET data corrected for the tissue shrinkage on the basis of MRI morphometry indicated a net reduction in cerebellar CMRO2 and CBE The present study has demonstrated that a combination of functional and anatomical data offers further evidence in favour of the current acceptable classification of SCD based on clinicopathological grounds. Our data further suggest that the amount of atrophy in the cerebellum could not fully account for the decreased metabolic rates observed in PET studies.
AB - Fourteen patients with spinocerebellar degeneration (SCD) were subjected to MRI and PET studies. The quantitative MRI data revealed significant cerebellar and pontine atrophy in the patients with olivopontocerebellar atrophy (OPCA), and cerebellar atrophy in the patients with late cerebellar cortical atrophy (LCCA). We failed to demonstrate significant differences in the pons between LCCA patients and normal controls. PET measurements revealed decreases in cerebral oxygen metabolic rate (CMRO2) in the cerebellar hemisphere and vermis in both groups of patients. The markedly decreased cerebral blood flow (CBF) and CMRO2 in the pons were found only in the patients with OPCA. PET data corrected for the tissue shrinkage on the basis of MRI morphometry indicated a net reduction in cerebellar CMRO2 and CBE The present study has demonstrated that a combination of functional and anatomical data offers further evidence in favour of the current acceptable classification of SCD based on clinicopathological grounds. Our data further suggest that the amount of atrophy in the cerebellum could not fully account for the decreased metabolic rates observed in PET studies.
KW - Cerebellar metabolism
KW - Late cerebellar cortical atrophy
KW - Magnetic resonance imaging
KW - Olivopontocerebellar atrophy
KW - Positron emission tomography
UR - http://www.scopus.com/inward/record.url?scp=0028215482&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028215482&partnerID=8YFLogxK
U2 - 10.1007/BF00868436
DO - 10.1007/BF00868436
M3 - Article
C2 - 8006682
AN - SCOPUS:0028215482
VL - 241
SP - 295
EP - 300
JO - Journal of Neurology
JF - Journal of Neurology
SN - 0340-5354
IS - 5
ER -