Reduced cerebellar blood flow and oxygen metabolism in spinocerebellar degeneration: a combined PET and MRI study

Xiaoyan Sun, Makoto Tanaka, Susumu Kondo, Shunsaku Hirai, Tomio Ishihara

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Fourteen patients with spinocerebellar degeneration (SCD) were subjected to MRI and PET studies. The quantitative MRI data revealed significant cerebellar and pontine atrophy in the patients with olivopontocerebellar atrophy (OPCA), and cerebellar atrophy in the patients with late cerebellar cortical atrophy (LCCA). We failed to demonstrate significant differences in the pons between LCCA patients and normal controls. PET measurements revealed decreases in cerebral oxygen metabolic rate (CMRO2) in the cerebellar hemisphere and vermis in both groups of patients. The markedly decreased cerebral blood flow (CBF) and CMRO2 in the pons were found only in the patients with OPCA. PET data corrected for the tissue shrinkage on the basis of MRI morphometry indicated a net reduction in cerebellar CMRO2 and CBE The present study has demonstrated that a combination of functional and anatomical data offers further evidence in favour of the current acceptable classification of SCD based on clinicopathological grounds. Our data further suggest that the amount of atrophy in the cerebellum could not fully account for the decreased metabolic rates observed in PET studies.

Original languageEnglish (US)
Pages (from-to)295-300
Number of pages6
JournalJournal of Neurology
Volume241
Issue number5
DOIs
StatePublished - May 1994
Externally publishedYes

Fingerprint

Spinocerebellar Degenerations
Atrophy
Oxygen
Olivopontocerebellar Atrophies
Pons
Cerebrovascular Circulation
Cerebellum

Keywords

  • Cerebellar metabolism
  • Late cerebellar cortical atrophy
  • Magnetic resonance imaging
  • Olivopontocerebellar atrophy
  • Positron emission tomography

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Reduced cerebellar blood flow and oxygen metabolism in spinocerebellar degeneration : a combined PET and MRI study. / Sun, Xiaoyan; Tanaka, Makoto; Kondo, Susumu; Hirai, Shunsaku; Ishihara, Tomio.

In: Journal of Neurology, Vol. 241, No. 5, 05.1994, p. 295-300.

Research output: Contribution to journalArticle

Sun, Xiaoyan ; Tanaka, Makoto ; Kondo, Susumu ; Hirai, Shunsaku ; Ishihara, Tomio. / Reduced cerebellar blood flow and oxygen metabolism in spinocerebellar degeneration : a combined PET and MRI study. In: Journal of Neurology. 1994 ; Vol. 241, No. 5. pp. 295-300.
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