Redox signaling pathways involved in neuronal ischemic preconditioning

John W. Thompson, Srinivasan V. Narayanan, Miguel Perez-Pinzon

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

There is extensive evidence that the restoration of blood flow following cerebral ischemia contributes greatly to the pathophysiology of ischemia mediated brain injury. The initiating stimulus of reperfusion injury is believed to be the excessive production of reactive oxygen (ROS) and nitrogen (RNS) species by the mitochondria. ROS and RNS generation leads to mitochondrial protein, lipid and DNA oxidation which impedes normal mitochondrial physiology and initiates cellular death pathways. However not all ROS and RNS production is detrimental. It has been demonstrated that low levels of ROS production are protective and may serve as a trigger for activation of ischemic preconditioning. Ischemic preconditioning is a neuroprotective mechanism which is activated upon a brief sublethal ischemic exposure and is sufficient to provide protection against a subsequent lethal ischemic insult. Numerous proteins and signaling pathways have been implicated in the ischemic preconditioning neuroprotective response. In this review we examine the origin and mechanisms of ROS and RNS production following ischemic/reperfusion and the role of free radicals in modulating proteins associated with ischemic preconditioning neuroprotection.

Original languageEnglish
Pages (from-to)354-369
Number of pages16
JournalCurrent Neuropharmacology
Volume10
Issue number4
StatePublished - Dec 1 2012

Fingerprint

Ischemic Preconditioning
Oxidation-Reduction
Mitochondrial Proteins
Reperfusion Injury
Brain Ischemia
Mitochondrial DNA
Brain Injuries
Reperfusion
Free Radicals
Mitochondria
Proteins
Nitrogen
Ischemia
Oxygen
Lipids

Keywords

  • Epsilon PKC
  • HIF
  • Ischemic preconditioning
  • Nrf2
  • Reactive oxygen species
  • Reperfusion
  • SIRT1
  • Sirtuin

ASJC Scopus subject areas

  • Clinical Neurology
  • Pharmacology (medical)
  • Pharmacology
  • Neurology
  • Psychiatry and Mental health

Cite this

Redox signaling pathways involved in neuronal ischemic preconditioning. / Thompson, John W.; Narayanan, Srinivasan V.; Perez-Pinzon, Miguel.

In: Current Neuropharmacology, Vol. 10, No. 4, 01.12.2012, p. 354-369.

Research output: Contribution to journalArticle

Thompson, John W. ; Narayanan, Srinivasan V. ; Perez-Pinzon, Miguel. / Redox signaling pathways involved in neuronal ischemic preconditioning. In: Current Neuropharmacology. 2012 ; Vol. 10, No. 4. pp. 354-369.
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