Redox Mechanisms in Migraine: Novel Therapeutics and Dietary Interventions

Patrizia Ferroni, Piero Barbanti, David Della Morte, Raffaele Palmirotta, Emilio Jirillo, Fiorella Guadagni

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Significance: Migraine represents the third most prevalent and the seventh most disabling human disorder. Approximately 30% of migraine patients experience transient, fully reversible, focal neurological symptoms (aura) preceding the attack. Recent Advances: Awareness of the hypothesis that migraine actually embodies a spectrum of illnesses - ranging from episodic to chronic forms - is progressively increasing and poses novel challenges for clarifying the underlying pathophysiological mechanisms of migraine as well as for the development of novel therapeutic interventions. Several theories have evolved to the current concept that a combination of genetic, epigenetic, and environmental factors may play a role in migraine pathogenesis, although their relative importance is still being debated. Critical Issues: One critical issue that deserves a particular attention is the role of oxidative stress in migraine. Indeed, potentially harmful oxidative events occur during the migraine attack and long-lasting or frequent migraine episodes may increase brain exposure to oxidative events that can lead to chronic transformation. Moreover, a wide variety of dietary, environmental, physiological, behavioral, and pharmacological migraine triggers may act through oxidative stress, with clear implications for migraine treatment and prophylaxis. Interestingly, almost all current prophylactic migraine agents exert antioxidant effects. Future Directions: Increasing awareness of the role of oxidative stress and/or decreased antioxidant defenses in migraine pathogenesis and progression to a chronic condition lays the foundations for the design of novel prophylactic approaches, which, by reducing brain oxidative phenomena, could favorably modify the clinical course of migraine. Antioxid. Redox Signal. 28, 1144-1183.

Original languageEnglish (US)
Pages (from-to)1144-1183
Number of pages40
JournalAntioxidants and Redox Signaling
Volume28
Issue number12
DOIs
StatePublished - Apr 20 2018
Externally publishedYes

Fingerprint

Oxidative stress
Migraine Disorders
Oxidation-Reduction
Brain
Antioxidants
Therapeutics
Oxidative Stress
Epigenomics
Epilepsy

Keywords

  • biomarkers
  • headache
  • inflammation
  • migraine
  • nutraceuticals
  • oxidant stress
  • therapeutics

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

Cite this

Redox Mechanisms in Migraine : Novel Therapeutics and Dietary Interventions. / Ferroni, Patrizia; Barbanti, Piero; Della Morte, David; Palmirotta, Raffaele; Jirillo, Emilio; Guadagni, Fiorella.

In: Antioxidants and Redox Signaling, Vol. 28, No. 12, 20.04.2018, p. 1144-1183.

Research output: Contribution to journalReview article

Ferroni, P, Barbanti, P, Della Morte, D, Palmirotta, R, Jirillo, E & Guadagni, F 2018, 'Redox Mechanisms in Migraine: Novel Therapeutics and Dietary Interventions', Antioxidants and Redox Signaling, vol. 28, no. 12, pp. 1144-1183. https://doi.org/10.1089/ars.2017.7260
Ferroni, Patrizia ; Barbanti, Piero ; Della Morte, David ; Palmirotta, Raffaele ; Jirillo, Emilio ; Guadagni, Fiorella. / Redox Mechanisms in Migraine : Novel Therapeutics and Dietary Interventions. In: Antioxidants and Redox Signaling. 2018 ; Vol. 28, No. 12. pp. 1144-1183.
@article{e85921f625264414b1da0907ab072657,
title = "Redox Mechanisms in Migraine: Novel Therapeutics and Dietary Interventions",
abstract = "Significance: Migraine represents the third most prevalent and the seventh most disabling human disorder. Approximately 30{\%} of migraine patients experience transient, fully reversible, focal neurological symptoms (aura) preceding the attack. Recent Advances: Awareness of the hypothesis that migraine actually embodies a spectrum of illnesses - ranging from episodic to chronic forms - is progressively increasing and poses novel challenges for clarifying the underlying pathophysiological mechanisms of migraine as well as for the development of novel therapeutic interventions. Several theories have evolved to the current concept that a combination of genetic, epigenetic, and environmental factors may play a role in migraine pathogenesis, although their relative importance is still being debated. Critical Issues: One critical issue that deserves a particular attention is the role of oxidative stress in migraine. Indeed, potentially harmful oxidative events occur during the migraine attack and long-lasting or frequent migraine episodes may increase brain exposure to oxidative events that can lead to chronic transformation. Moreover, a wide variety of dietary, environmental, physiological, behavioral, and pharmacological migraine triggers may act through oxidative stress, with clear implications for migraine treatment and prophylaxis. Interestingly, almost all current prophylactic migraine agents exert antioxidant effects. Future Directions: Increasing awareness of the role of oxidative stress and/or decreased antioxidant defenses in migraine pathogenesis and progression to a chronic condition lays the foundations for the design of novel prophylactic approaches, which, by reducing brain oxidative phenomena, could favorably modify the clinical course of migraine. Antioxid. Redox Signal. 28, 1144-1183.",
keywords = "biomarkers, headache, inflammation, migraine, nutraceuticals, oxidant stress, therapeutics",
author = "Patrizia Ferroni and Piero Barbanti and {Della Morte}, David and Raffaele Palmirotta and Emilio Jirillo and Fiorella Guadagni",
year = "2018",
month = "4",
day = "20",
doi = "10.1089/ars.2017.7260",
language = "English (US)",
volume = "28",
pages = "1144--1183",
journal = "Antioxidants and Redox Signaling",
issn = "1523-0864",
publisher = "Mary Ann Liebert Inc.",
number = "12",

}

TY - JOUR

T1 - Redox Mechanisms in Migraine

T2 - Novel Therapeutics and Dietary Interventions

AU - Ferroni, Patrizia

AU - Barbanti, Piero

AU - Della Morte, David

AU - Palmirotta, Raffaele

AU - Jirillo, Emilio

AU - Guadagni, Fiorella

PY - 2018/4/20

Y1 - 2018/4/20

N2 - Significance: Migraine represents the third most prevalent and the seventh most disabling human disorder. Approximately 30% of migraine patients experience transient, fully reversible, focal neurological symptoms (aura) preceding the attack. Recent Advances: Awareness of the hypothesis that migraine actually embodies a spectrum of illnesses - ranging from episodic to chronic forms - is progressively increasing and poses novel challenges for clarifying the underlying pathophysiological mechanisms of migraine as well as for the development of novel therapeutic interventions. Several theories have evolved to the current concept that a combination of genetic, epigenetic, and environmental factors may play a role in migraine pathogenesis, although their relative importance is still being debated. Critical Issues: One critical issue that deserves a particular attention is the role of oxidative stress in migraine. Indeed, potentially harmful oxidative events occur during the migraine attack and long-lasting or frequent migraine episodes may increase brain exposure to oxidative events that can lead to chronic transformation. Moreover, a wide variety of dietary, environmental, physiological, behavioral, and pharmacological migraine triggers may act through oxidative stress, with clear implications for migraine treatment and prophylaxis. Interestingly, almost all current prophylactic migraine agents exert antioxidant effects. Future Directions: Increasing awareness of the role of oxidative stress and/or decreased antioxidant defenses in migraine pathogenesis and progression to a chronic condition lays the foundations for the design of novel prophylactic approaches, which, by reducing brain oxidative phenomena, could favorably modify the clinical course of migraine. Antioxid. Redox Signal. 28, 1144-1183.

AB - Significance: Migraine represents the third most prevalent and the seventh most disabling human disorder. Approximately 30% of migraine patients experience transient, fully reversible, focal neurological symptoms (aura) preceding the attack. Recent Advances: Awareness of the hypothesis that migraine actually embodies a spectrum of illnesses - ranging from episodic to chronic forms - is progressively increasing and poses novel challenges for clarifying the underlying pathophysiological mechanisms of migraine as well as for the development of novel therapeutic interventions. Several theories have evolved to the current concept that a combination of genetic, epigenetic, and environmental factors may play a role in migraine pathogenesis, although their relative importance is still being debated. Critical Issues: One critical issue that deserves a particular attention is the role of oxidative stress in migraine. Indeed, potentially harmful oxidative events occur during the migraine attack and long-lasting or frequent migraine episodes may increase brain exposure to oxidative events that can lead to chronic transformation. Moreover, a wide variety of dietary, environmental, physiological, behavioral, and pharmacological migraine triggers may act through oxidative stress, with clear implications for migraine treatment and prophylaxis. Interestingly, almost all current prophylactic migraine agents exert antioxidant effects. Future Directions: Increasing awareness of the role of oxidative stress and/or decreased antioxidant defenses in migraine pathogenesis and progression to a chronic condition lays the foundations for the design of novel prophylactic approaches, which, by reducing brain oxidative phenomena, could favorably modify the clinical course of migraine. Antioxid. Redox Signal. 28, 1144-1183.

KW - biomarkers

KW - headache

KW - inflammation

KW - migraine

KW - nutraceuticals

KW - oxidant stress

KW - therapeutics

UR - http://www.scopus.com/inward/record.url?scp=85044632682&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85044632682&partnerID=8YFLogxK

U2 - 10.1089/ars.2017.7260

DO - 10.1089/ars.2017.7260

M3 - Review article

C2 - 28990418

AN - SCOPUS:85044632682

VL - 28

SP - 1144

EP - 1183

JO - Antioxidants and Redox Signaling

JF - Antioxidants and Redox Signaling

SN - 1523-0864

IS - 12

ER -