Recently, it has been shown that VEPs to pure chromatic contrast represent a useful tool for earlier diagnosis and better understanding of the pathophysiology of Multiple Sclerosis (MS). Aim of this study was to compare responses to red-green and blueyellow stimuli, which reflect the contribution of different streams of the parvocellular pathway. In 25 patients with different form of MS we recorded VEPs in response to full-field equiluminant red-green or blue-yellow gratings, 2 cpd, presented in OnsetOffset mode (300 msec On-, 700msec Off) at two contrast levels (90% and 25%). Responses were compared with conventional luminance checkerboard VEPs. On average, chromatic VEPs were more altered in amplitude and latency than luminance VEPs; in some patients the impairment of chromatic responses was of different extent for red-gren or blue-yellow stimuli. In conclusion, chromatic VEPs, as compared to luminance VEPs, appear to reveal earlier and more subtle losses in MS, suggesting different vulnerability of different streams of the visual pathway.
|Journal||Italian Journal of Neurological Sciences|
|State||Published - Dec 1 1997|
ASJC Scopus subject areas
- Clinical Neurology