Recurrent risk of adverse events in medically treated patients with patent foramen ovale: A review of the literature

Shunichi Homma, Robert R. Sciacca, Yukiko Oe, Tarjana Rundek, Ralph L. Sacco, Marco R. Di Tullio

Research output: Contribution to journalReview articlepeer-review

Abstract

Patent foramen ovale is associated with stroke. However, the rate of recurrent events in medically treated patients with patent foramen ovale remains undefined. Estimates differ by the studies. In order to provide a more accurate estimate of the recurrent adverse event rates in medically treated patients with patent foramen ovale, we reviewed the literature and analyzed the results from a total of 1,108 patients combining 12 studies. We found the annual rate of stroke or death to be 3.12% (95% CI, 2.32-4.11%). This estimate will provide a valuable guideline for any future study to compare the efficacy of other modalities such as percutaneous device closure of patent foramen ovale with medical treatment.

Original languageEnglish (US)
Pages (from-to)269-276
Number of pages8
JournalActa Clinica Croatica
Volume42
Issue number3
StatePublished - Sep 1 2003
Externally publishedYes

Keywords

  • Cerbrovascular disorders, complications
  • Cerebrovascular accident, etiology
  • Heart septal defects
  • Prognosis
  • Risk factors

ASJC Scopus subject areas

  • Medicine(all)

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