Recurrent intrahepatic pigmented stones after liver transplantation in a patient with hemoglobin SC disease: Case report and review of the literature

Juli Tomaino, Tara Keegan, Nanda Kerkar, Marcelo Facciuto, Tamir Miloh, Bachir Taouli, Anne Hurlet, Joshua Weintraub, Divyesh Sejpal, Ronen Arnon

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Patients with hemoglobinopathies may have hepatic involvement, which if severe, can lead to chronic liver disease and a need for liver transplant. Here, we present a case of a 16-yr-old female adolescent who presented to our center with hemoglobin SC disease, obstructive jaundice because of pigmented intrahepatic biliary stones, and progressive liver disease. She underwent a successful liver transplant but a few years later, she developed recurrent cholangitis and graft dysfunction because of recurrent intrahepatic biliary stones. Recurrent formation of intrahepatic stones after liver transplant is a rare and severe complication in patients with hemoglobinopathies. We recommend hypertransfusion therapy and surveillance imaging studies after liver transplant for early detection and prevention of this complication.

Original languageEnglish (US)
Pages (from-to)519-524
Number of pages6
JournalPediatric Transplantation
Volume15
Issue number5
DOIs
StatePublished - Aug 2011
Externally publishedYes

Keywords

  • complications of liver transplantation
  • graft survival
  • liver transplant

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Transplantation

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