Abstract
BACKGROUND. Risk of basal cell carcinoma (BCC) recurrence appears to be related to tumor location, tumor size, treatment modality, radicalness of excision, and histologic type. Recurrences of BCC on the trunk and extremities are rate, with 97% of all recurrent lesions being located in the head and neck region. OBJECTIVE. This report concerns a man who had a BCC of the back removed with electrodesiccation and curettage in 1980 at the age of 36. In the following 10 years the patient experienced five recurrences and finally developed infiltration of the thoracic spine that precluded further attempts at radical excision of the neoplasm. METHODS AND RESULTS. The pathology of the BCC in our patient revealed a number of histologic features that have been associated with aggressive behaviour. These include an infiltrative growth pattern characterized by an irregular and acute tapered profile of the tumor cell groups and fibroblast-rich stroma, infiltrating invading tumour edges, poorly peripheral palisading, nuclear pleomorphism, and perineural invasion. CONCLUSION. Basal cell carcinomas that occur in sunlight-protected areas of the trunk of middle-aged individuals can occasionally exhibit aggressive and highly invasive features as well as a marked tendency for local uncontrollable recurrences. The prognosis for patients with this variety of BCC is poor, especially when progressive infiltration of deep tissues does not permit, as in our case, any possible further radical surgical procedure.
| Original language | English |
|---|---|
| Pages (from-to) | 917-922 |
| Number of pages | 6 |
| Journal | Journal of Dermatologic Surgery and Oncology |
| Volume | 19 |
| Issue number | 10 |
| State | Published - Dec 1 1993 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Dermatology
- Oncology
Cite this
Recurrent basal cell carcinoma of the back infiltrating the spine : Recurrent basal cell carcinoma. / Morselli, P.; Tosti, Antonella; Guerra, L.; Fanti, P. A.; Fedeli, F.; Pistorale, T.; Cavina, C.; Varotti, C.
In: Journal of Dermatologic Surgery and Oncology, Vol. 19, No. 10, 01.12.1993, p. 917-922.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Recurrent basal cell carcinoma of the back infiltrating the spine
T2 - Recurrent basal cell carcinoma
AU - Morselli, P.
AU - Tosti, Antonella
AU - Guerra, L.
AU - Fanti, P. A.
AU - Fedeli, F.
AU - Pistorale, T.
AU - Cavina, C.
AU - Varotti, C.
PY - 1993/12/1
Y1 - 1993/12/1
N2 - BACKGROUND. Risk of basal cell carcinoma (BCC) recurrence appears to be related to tumor location, tumor size, treatment modality, radicalness of excision, and histologic type. Recurrences of BCC on the trunk and extremities are rate, with 97% of all recurrent lesions being located in the head and neck region. OBJECTIVE. This report concerns a man who had a BCC of the back removed with electrodesiccation and curettage in 1980 at the age of 36. In the following 10 years the patient experienced five recurrences and finally developed infiltration of the thoracic spine that precluded further attempts at radical excision of the neoplasm. METHODS AND RESULTS. The pathology of the BCC in our patient revealed a number of histologic features that have been associated with aggressive behaviour. These include an infiltrative growth pattern characterized by an irregular and acute tapered profile of the tumor cell groups and fibroblast-rich stroma, infiltrating invading tumour edges, poorly peripheral palisading, nuclear pleomorphism, and perineural invasion. CONCLUSION. Basal cell carcinomas that occur in sunlight-protected areas of the trunk of middle-aged individuals can occasionally exhibit aggressive and highly invasive features as well as a marked tendency for local uncontrollable recurrences. The prognosis for patients with this variety of BCC is poor, especially when progressive infiltration of deep tissues does not permit, as in our case, any possible further radical surgical procedure.
AB - BACKGROUND. Risk of basal cell carcinoma (BCC) recurrence appears to be related to tumor location, tumor size, treatment modality, radicalness of excision, and histologic type. Recurrences of BCC on the trunk and extremities are rate, with 97% of all recurrent lesions being located in the head and neck region. OBJECTIVE. This report concerns a man who had a BCC of the back removed with electrodesiccation and curettage in 1980 at the age of 36. In the following 10 years the patient experienced five recurrences and finally developed infiltration of the thoracic spine that precluded further attempts at radical excision of the neoplasm. METHODS AND RESULTS. The pathology of the BCC in our patient revealed a number of histologic features that have been associated with aggressive behaviour. These include an infiltrative growth pattern characterized by an irregular and acute tapered profile of the tumor cell groups and fibroblast-rich stroma, infiltrating invading tumour edges, poorly peripheral palisading, nuclear pleomorphism, and perineural invasion. CONCLUSION. Basal cell carcinomas that occur in sunlight-protected areas of the trunk of middle-aged individuals can occasionally exhibit aggressive and highly invasive features as well as a marked tendency for local uncontrollable recurrences. The prognosis for patients with this variety of BCC is poor, especially when progressive infiltration of deep tissues does not permit, as in our case, any possible further radical surgical procedure.
UR - http://www.scopus.com/inward/record.url?scp=0027818949&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027818949&partnerID=8YFLogxK
M3 - Article
C2 - 8408910
AN - SCOPUS:0027818949
VL - 19
SP - 917
EP - 922
JO - Dermatologic Surgery
JF - Dermatologic Surgery
SN - 1076-0512
IS - 10
ER -