Recurrent and De Novo Autoimmune Liver Diseases

Flavia Mendes, Claudia A. Couto, Cynthia Levy

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC), and autoimmune hepatitis (AIH) each account for approximately 5% of liver transplants per year performed in the United States and Europe. Even though outcomes are excellent, with reported 5-year patient and graft survival exceeding 90% and 80%, 80% and 75%, 72% and 65% for PBC, PSC, and AIH, respectively, the issue of recurrent autoimmune liver disease after orthotopic liver transplantation is increasingly recognized as a cause of graft dysfunction, death, and need for retransplantation. This article reviews diagnostic criteria, epidemiology, risk factors, and outcomes of recurrent PBC, PSC, and AIH after liver transplantation.

Original languageEnglish
Pages (from-to)859-878
Number of pages20
JournalClinics in Liver Disease
Volume15
Issue number4
DOIs
StatePublished - Nov 1 2011

Fingerprint

Autoimmune Hepatitis
Sclerosing Cholangitis
Biliary Liver Cirrhosis
Autoimmune Diseases
Liver Diseases
Liver Transplantation
Transplants
Graft Survival
Epidemiology
Liver

Keywords

  • Autoimmune hepatitis
  • Liver transplantation
  • Primary biliary cirrhosis
  • Primary sclerosing cholangitis
  • Recurrence

ASJC Scopus subject areas

  • Hepatology

Cite this

Recurrent and De Novo Autoimmune Liver Diseases. / Mendes, Flavia; Couto, Claudia A.; Levy, Cynthia.

In: Clinics in Liver Disease, Vol. 15, No. 4, 01.11.2011, p. 859-878.

Research output: Contribution to journalArticle

Mendes, Flavia ; Couto, Claudia A. ; Levy, Cynthia. / Recurrent and De Novo Autoimmune Liver Diseases. In: Clinics in Liver Disease. 2011 ; Vol. 15, No. 4. pp. 859-878.
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