Recurrent and De Novo Autoimmune Liver Diseases

Flavia Mendes, Claudia A. Couto, Cynthia Levy

Research output: Contribution to journalReview article

22 Scopus citations

Abstract

Primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC), and autoimmune hepatitis (AIH) each account for approximately 5% of liver transplants per year performed in the United States and Europe. Even though outcomes are excellent, with reported 5-year patient and graft survival exceeding 90% and 80%, 80% and 75%, 72% and 65% for PBC, PSC, and AIH, respectively, the issue of recurrent autoimmune liver disease after orthotopic liver transplantation is increasingly recognized as a cause of graft dysfunction, death, and need for retransplantation. This article reviews diagnostic criteria, epidemiology, risk factors, and outcomes of recurrent PBC, PSC, and AIH after liver transplantation.

Original languageEnglish (US)
Pages (from-to)859-878
Number of pages20
JournalClinics in liver disease
Volume15
Issue number4
DOIs
StatePublished - Nov 1 2011

Keywords

  • Autoimmune hepatitis
  • Liver transplantation
  • Primary biliary cirrhosis
  • Primary sclerosing cholangitis
  • Recurrence

ASJC Scopus subject areas

  • Hepatology

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