Abstract
Primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC), and autoimmune hepatitis (AIH) each account for approximately 5% of liver transplants per year performed in the United States and Europe. Even though outcomes are excellent, with reported 5-year patient and graft survival exceeding 90% and 80%, 80% and 75%, 72% and 65% for PBC, PSC, and AIH, respectively, the issue of recurrent autoimmune liver disease after orthotopic liver transplantation is increasingly recognized as a cause of graft dysfunction, death, and need for retransplantation. This article reviews diagnostic criteria, epidemiology, risk factors, and outcomes of recurrent PBC, PSC, and AIH after liver transplantation.
| Original language | English |
|---|---|
| Pages (from-to) | 859-878 |
| Number of pages | 20 |
| Journal | Clinics in Liver Disease |
| Volume | 15 |
| Issue number | 4 |
| DOIs | |
| State | Published - Nov 1 2011 |
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Keywords
- Autoimmune hepatitis
- Liver transplantation
- Primary biliary cirrhosis
- Primary sclerosing cholangitis
- Recurrence
ASJC Scopus subject areas
- Hepatology
Cite this
Recurrent and De Novo Autoimmune Liver Diseases. / Mendes, Flavia; Couto, Claudia A.; Levy, Cynthia.
In: Clinics in Liver Disease, Vol. 15, No. 4, 01.11.2011, p. 859-878.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Recurrent and De Novo Autoimmune Liver Diseases
AU - Mendes, Flavia
AU - Couto, Claudia A.
AU - Levy, Cynthia
PY - 2011/11/1
Y1 - 2011/11/1
N2 - Primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC), and autoimmune hepatitis (AIH) each account for approximately 5% of liver transplants per year performed in the United States and Europe. Even though outcomes are excellent, with reported 5-year patient and graft survival exceeding 90% and 80%, 80% and 75%, 72% and 65% for PBC, PSC, and AIH, respectively, the issue of recurrent autoimmune liver disease after orthotopic liver transplantation is increasingly recognized as a cause of graft dysfunction, death, and need for retransplantation. This article reviews diagnostic criteria, epidemiology, risk factors, and outcomes of recurrent PBC, PSC, and AIH after liver transplantation.
AB - Primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC), and autoimmune hepatitis (AIH) each account for approximately 5% of liver transplants per year performed in the United States and Europe. Even though outcomes are excellent, with reported 5-year patient and graft survival exceeding 90% and 80%, 80% and 75%, 72% and 65% for PBC, PSC, and AIH, respectively, the issue of recurrent autoimmune liver disease after orthotopic liver transplantation is increasingly recognized as a cause of graft dysfunction, death, and need for retransplantation. This article reviews diagnostic criteria, epidemiology, risk factors, and outcomes of recurrent PBC, PSC, and AIH after liver transplantation.
KW - Autoimmune hepatitis
KW - Liver transplantation
KW - Primary biliary cirrhosis
KW - Primary sclerosing cholangitis
KW - Recurrence
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UR - http://www.scopus.com/inward/citedby.url?scp=80054962713&partnerID=8YFLogxK
U2 - 10.1016/j.cld.2011.08.008
DO - 10.1016/j.cld.2011.08.008
M3 - Article
C2 - 22032533
AN - SCOPUS:80054962713
VL - 15
SP - 859
EP - 878
JO - Clinics in Liver Disease
JF - Clinics in Liver Disease
SN - 1089-3261
IS - 4
ER -