TY - JOUR
T1 - Recurrent and De Novo Autoimmune Liver Diseases
AU - Mendes, Flavia
AU - Couto, Claudia A.
AU - Levy, Cynthia
PY - 2011/11/1
Y1 - 2011/11/1
N2 - Primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC), and autoimmune hepatitis (AIH) each account for approximately 5% of liver transplants per year performed in the United States and Europe. Even though outcomes are excellent, with reported 5-year patient and graft survival exceeding 90% and 80%, 80% and 75%, 72% and 65% for PBC, PSC, and AIH, respectively, the issue of recurrent autoimmune liver disease after orthotopic liver transplantation is increasingly recognized as a cause of graft dysfunction, death, and need for retransplantation. This article reviews diagnostic criteria, epidemiology, risk factors, and outcomes of recurrent PBC, PSC, and AIH after liver transplantation.
AB - Primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC), and autoimmune hepatitis (AIH) each account for approximately 5% of liver transplants per year performed in the United States and Europe. Even though outcomes are excellent, with reported 5-year patient and graft survival exceeding 90% and 80%, 80% and 75%, 72% and 65% for PBC, PSC, and AIH, respectively, the issue of recurrent autoimmune liver disease after orthotopic liver transplantation is increasingly recognized as a cause of graft dysfunction, death, and need for retransplantation. This article reviews diagnostic criteria, epidemiology, risk factors, and outcomes of recurrent PBC, PSC, and AIH after liver transplantation.
KW - Autoimmune hepatitis
KW - Liver transplantation
KW - Primary biliary cirrhosis
KW - Primary sclerosing cholangitis
KW - Recurrence
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U2 - 10.1016/j.cld.2011.08.008
DO - 10.1016/j.cld.2011.08.008
M3 - Review article
C2 - 22032533
AN - SCOPUS:80054962713
VL - 15
SP - 859
EP - 878
JO - Clinics in Liver Disease
JF - Clinics in Liver Disease
SN - 1089-3261
IS - 4
ER -