Recurrent adult-type fibrosarcoma of the frontal bone in a child

Mariangela Novello, Concezio Di Rocco, Gianpiero Tamburrini, Paolo Frassanito, Daniel T. Aguirre, Andrew E. Rosenberg, Antonella Coli

Research output: Contribution to journalArticle

Abstract

Introduction: Primary, adult-type bone fibrosarcoma is an uncommon, malignant spindle-cell tumor of fibroblastic origin, rarely affecting children. Most frequently diagnosed among bone malignancies in the past, improved diagnostic techniques and further restrictive classification criteria have currently made the diagnosis of fibrosarcoma very unusual. Case report: We hereby report the case of a 7-year-old child with a right frontal swelling mass. A computed tomography scan showed an osteolytic lesion of the right frontal bone, involving the diploe and the outer table of the skull. An en bloc surgical excision, followed by a thorough immunohistological evaluation, led to the diagnosis of fibroblastic proliferation, with low cellularity and minimal atypias. The patient had four recurrences during the 4-year follow-up. With an increasing histological grade at recurrences, a diagnosis of adult-type fibrosarcoma was made. Conclusion: To the best of the authors’ knowledge, this is the first reported case of an adult-type fibrosarcoma arising in the frontal bone of a child.

Original languageEnglish (US)
Pages (from-to)1169-1173
Number of pages5
JournalChild's Nervous System
Volume32
Issue number6
DOIs
StatePublished - Jun 1 2016

Keywords

  • Fibrosarcoma
  • Frontal bone
  • Immunohistochemistry
  • Molecular biology
  • Pediatric
  • Tumor progression

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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  • Cite this

    Novello, M., Di Rocco, C., Tamburrini, G., Frassanito, P., Aguirre, D. T., Rosenberg, A. E., & Coli, A. (2016). Recurrent adult-type fibrosarcoma of the frontal bone in a child. Child's Nervous System, 32(6), 1169-1173. https://doi.org/10.1007/s00381-015-2998-6