TY - JOUR
T1 - Recurrent adult-type fibrosarcoma of the frontal bone in a child
AU - Novello, Mariangela
AU - Di Rocco, Concezio
AU - Tamburrini, Gianpiero
AU - Frassanito, Paolo
AU - Aguirre, Daniel T.
AU - Rosenberg, Andrew E.
AU - Coli, Antonella
PY - 2016/6/1
Y1 - 2016/6/1
N2 - Introduction: Primary, adult-type bone fibrosarcoma is an uncommon, malignant spindle-cell tumor of fibroblastic origin, rarely affecting children. Most frequently diagnosed among bone malignancies in the past, improved diagnostic techniques and further restrictive classification criteria have currently made the diagnosis of fibrosarcoma very unusual. Case report: We hereby report the case of a 7-year-old child with a right frontal swelling mass. A computed tomography scan showed an osteolytic lesion of the right frontal bone, involving the diploe and the outer table of the skull. An en bloc surgical excision, followed by a thorough immunohistological evaluation, led to the diagnosis of fibroblastic proliferation, with low cellularity and minimal atypias. The patient had four recurrences during the 4-year follow-up. With an increasing histological grade at recurrences, a diagnosis of adult-type fibrosarcoma was made. Conclusion: To the best of the authors’ knowledge, this is the first reported case of an adult-type fibrosarcoma arising in the frontal bone of a child.
AB - Introduction: Primary, adult-type bone fibrosarcoma is an uncommon, malignant spindle-cell tumor of fibroblastic origin, rarely affecting children. Most frequently diagnosed among bone malignancies in the past, improved diagnostic techniques and further restrictive classification criteria have currently made the diagnosis of fibrosarcoma very unusual. Case report: We hereby report the case of a 7-year-old child with a right frontal swelling mass. A computed tomography scan showed an osteolytic lesion of the right frontal bone, involving the diploe and the outer table of the skull. An en bloc surgical excision, followed by a thorough immunohistological evaluation, led to the diagnosis of fibroblastic proliferation, with low cellularity and minimal atypias. The patient had four recurrences during the 4-year follow-up. With an increasing histological grade at recurrences, a diagnosis of adult-type fibrosarcoma was made. Conclusion: To the best of the authors’ knowledge, this is the first reported case of an adult-type fibrosarcoma arising in the frontal bone of a child.
KW - Fibrosarcoma
KW - Frontal bone
KW - Immunohistochemistry
KW - Molecular biology
KW - Pediatric
KW - Tumor progression
UR - http://www.scopus.com/inward/record.url?scp=84953401393&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84953401393&partnerID=8YFLogxK
U2 - 10.1007/s00381-015-2998-6
DO - 10.1007/s00381-015-2998-6
M3 - Article
C2 - 26743922
AN - SCOPUS:84953401393
VL - 32
SP - 1169
EP - 1173
JO - Child's Nervous System
JF - Child's Nervous System
SN - 0256-7040
IS - 6
ER -