Recurrence of Posterior Uveal Melanoma after 60Co Episcleral Plaque Therapy

Ulf L. Karlsson, James J. Augsburger, Jerry A. Shields, Arnold M. Markoe, Luther W. Brady, Reginald Woodleigh

Research output: Contribution to journalArticlepeer-review

85 Scopus citations


The authors analyzed the clinical and follow-up data on 277 selected patients with primary choroidal or ciliochoroidal melanoma who where treated with 60Co plaque radiotherapy between 1976 and 1982. Local recurrence of the irradiated melanoma developed in 39 (14%) patients during the follow-up interval. The 5-year tumor recurrence rate (Kaplan-Meier) was estimated to be 12%. Multivariate prognostic factor analysis (Cox proportional hazards modeling) identified the largest linear tumor dimension and proximity of the posterior margin of the tumor to the optic nerve head as predictors of recurrence. The 5-year survival rate of patients whose tumors recurred (58%) was significantly (log-rank test P = 0.0023) worse than that of patients whose tumor remained clinically controlled (82%).

Original languageEnglish (US)
Pages (from-to)382-388
Number of pages7
Issue number3
StatePublished - 1989
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology


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