Recurrence and clearance of hepatitis B surface antigenemia in a dialysis patient infected with the human immunodeficiency virus

C. J. Ortiz-Interian, M. D. De Medina, G. O. Perez, J. J. Bourgoignie, F. Watkins, E. Velez-Robinson, Eugene R Schiff

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Abstract

Hepatitis B vaccination programs have prevented infection in many dialysis patients, although the antibody response to vaccination is still insufficient in approximately 50%. Reinfection or reactivation of latent hepatitis B infection (HBV) has been reported in certain groups of immunosuppressed patients, including those infected with the human immunodeficiency virus (HIV-1). We report the reactivation or reinfection of HBV with resurgence of hepatitis B surface antigen in a dialysis patient coinfected with HIV-1. Thus, in dialysis patients with latent HBV infection, with undetectable hepatitis B surface antigen (HBsAg) levels, the potential exists to reactivate during immunosuppression associated with HIV-1 infection and/or end-stage renal disease. Reinfection with a different subtype is also possible. The development of hepatitis B surface antigenemia in this patient population creates a potential for transmission in the dialysis setting. This is of special concern since the number of patients infected with HIV-1 and with evidence of prior hepatitis B infection is increasing in urban units.

Original languageEnglish
Pages (from-to)154-156
Number of pages3
JournalAmerican Journal of Kidney Diseases
Volume16
Issue number2
StatePublished - Jan 1 1990

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ASJC Scopus subject areas

  • Nephrology

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Ortiz-Interian, C. J., De Medina, M. D., Perez, G. O., Bourgoignie, J. J., Watkins, F., Velez-Robinson, E., & Schiff, E. R. (1990). Recurrence and clearance of hepatitis B surface antigenemia in a dialysis patient infected with the human immunodeficiency virus. American Journal of Kidney Diseases, 16(2), 154-156.