Recurrence and Clearance of Hepatitis B Surface Antigenemia in a Dialysis Patient Infected With the Human Immunodeficiency Virus

Carmen J. Ortiz-Interian, Maria D. de Medina, Guido O. Perez, Jacques J. Bourgoignie, Frederica Watkins, Elsa Velez-Robinson, Eugene Schiff

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Hepatitis B vaccination programs have prevented infection in many dialysis patients, although the antibody response to vaccination is still insufficient in approximately 50%. Reinfection or reactivation of latent hepatitis B infection (HBV) has been reported in certain groups of immunosuppressed patients, including those infected with the human immunodeficiency virus (HIV-1). We report the reactivation or reinfection of HBV with resurgence of hepatitis B surface antigen in a dialysis patient coinfected with HIV-1. Thus, in dialysis patients with latent HBV infection, with undetectable hepatitis B surface antigen (HBsAg) levels, the potential exists to reactivate during immunosuppression associated with HIV-1 infection and/or end-stage renal disease. Reinfection with a different subtype is also possible. The development of hepatitis B surface antigenemia in this patient population creates a potential for transmission in the dialysis setting. This is of special concern since the number of patients infected with HIV-1 and with evidence of prior hepatitis B infection is increasing in urban units.

Original languageEnglish (US)
Pages (from-to)154-156
Number of pages3
JournalAmerican Journal of Kidney Diseases
Volume16
Issue number2
DOIs
StatePublished - Jan 1 1990

Keywords

  • Dialysis
  • hepatitis B
  • human immunodeficiency virus

ASJC Scopus subject areas

  • Nephrology

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