TY - JOUR
T1 - Recurrence and Clearance of Hepatitis B Surface Antigenemia in a Dialysis Patient Infected With the Human Immunodeficiency Virus
AU - Ortiz-Interian, Carmen J.
AU - de Medina, Maria D.
AU - Perez, Guido O.
AU - Bourgoignie, Jacques J.
AU - Watkins, Frederica
AU - Velez-Robinson, Elsa
AU - Schiff, Eugene
PY - 1990/1/1
Y1 - 1990/1/1
N2 - Hepatitis B vaccination programs have prevented infection in many dialysis patients, although the antibody response to vaccination is still insufficient in approximately 50%. Reinfection or reactivation of latent hepatitis B infection (HBV) has been reported in certain groups of immunosuppressed patients, including those infected with the human immunodeficiency virus (HIV-1). We report the reactivation or reinfection of HBV with resurgence of hepatitis B surface antigen in a dialysis patient coinfected with HIV-1. Thus, in dialysis patients with latent HBV infection, with undetectable hepatitis B surface antigen (HBsAg) levels, the potential exists to reactivate during immunosuppression associated with HIV-1 infection and/or end-stage renal disease. Reinfection with a different subtype is also possible. The development of hepatitis B surface antigenemia in this patient population creates a potential for transmission in the dialysis setting. This is of special concern since the number of patients infected with HIV-1 and with evidence of prior hepatitis B infection is increasing in urban units.
AB - Hepatitis B vaccination programs have prevented infection in many dialysis patients, although the antibody response to vaccination is still insufficient in approximately 50%. Reinfection or reactivation of latent hepatitis B infection (HBV) has been reported in certain groups of immunosuppressed patients, including those infected with the human immunodeficiency virus (HIV-1). We report the reactivation or reinfection of HBV with resurgence of hepatitis B surface antigen in a dialysis patient coinfected with HIV-1. Thus, in dialysis patients with latent HBV infection, with undetectable hepatitis B surface antigen (HBsAg) levels, the potential exists to reactivate during immunosuppression associated with HIV-1 infection and/or end-stage renal disease. Reinfection with a different subtype is also possible. The development of hepatitis B surface antigenemia in this patient population creates a potential for transmission in the dialysis setting. This is of special concern since the number of patients infected with HIV-1 and with evidence of prior hepatitis B infection is increasing in urban units.
KW - Dialysis
KW - hepatitis B
KW - human immunodeficiency virus
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U2 - 10.1016/S0272-6386(12)80571-3
DO - 10.1016/S0272-6386(12)80571-3
M3 - Article
C2 - 2382653
AN - SCOPUS:0024995094
VL - 16
SP - 154
EP - 156
JO - American Journal of Kidney Diseases
JF - American Journal of Kidney Diseases
SN - 0272-6386
IS - 2
ER -