Abstract
Injection of immunodeficient, aged mice with synthetic thymosin-α1, a 28 amino acid residues peptide, before carrier priming enhances helper activity. Helper activity was titrated in vitro by adding graded numbers of HRBC-primed spleen cells from aging mice to cultures containing a constant number of spleen cells from 3-month-old normal mice and TNP-HRBC. The in vitro anti-TNP response is enhanced if the aging mice are injected with microgram quantities of α1 before carrier priming. As suggested by the shape of the titration curves α1 appears to increase T cell-T cell cooperation involved in the generation of helper cell activity. The in vitro proliferative response of lymph node cells from OVA-primed aging mice is also restored by injection of α1. Thus, T-cell functions which are markedly reduced in senescence can be efficiently repaired by injection of synthetic thymosin-α1.
| Original language | English |
|---|---|
| Pages (from-to) | 384-391 |
| Number of pages | 8 |
| Journal | Cellular Immunology |
| Volume | 72 |
| Issue number | 2 |
| DOIs | |
| State | Published - Sep 15 1982 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cell Biology
- Immunology
Cite this
Recovery of T-cell functions in aged mice injected with synthetic thymosin-α1. / Frasca, Daniela; Garavini, Mauro; Doria, Gino.
In: Cellular Immunology, Vol. 72, No. 2, 15.09.1982, p. 384-391.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Recovery of T-cell functions in aged mice injected with synthetic thymosin-α1
AU - Frasca, Daniela
AU - Garavini, Mauro
AU - Doria, Gino
PY - 1982/9/15
Y1 - 1982/9/15
N2 - Injection of immunodeficient, aged mice with synthetic thymosin-α1, a 28 amino acid residues peptide, before carrier priming enhances helper activity. Helper activity was titrated in vitro by adding graded numbers of HRBC-primed spleen cells from aging mice to cultures containing a constant number of spleen cells from 3-month-old normal mice and TNP-HRBC. The in vitro anti-TNP response is enhanced if the aging mice are injected with microgram quantities of α1 before carrier priming. As suggested by the shape of the titration curves α1 appears to increase T cell-T cell cooperation involved in the generation of helper cell activity. The in vitro proliferative response of lymph node cells from OVA-primed aging mice is also restored by injection of α1. Thus, T-cell functions which are markedly reduced in senescence can be efficiently repaired by injection of synthetic thymosin-α1.
AB - Injection of immunodeficient, aged mice with synthetic thymosin-α1, a 28 amino acid residues peptide, before carrier priming enhances helper activity. Helper activity was titrated in vitro by adding graded numbers of HRBC-primed spleen cells from aging mice to cultures containing a constant number of spleen cells from 3-month-old normal mice and TNP-HRBC. The in vitro anti-TNP response is enhanced if the aging mice are injected with microgram quantities of α1 before carrier priming. As suggested by the shape of the titration curves α1 appears to increase T cell-T cell cooperation involved in the generation of helper cell activity. The in vitro proliferative response of lymph node cells from OVA-primed aging mice is also restored by injection of α1. Thus, T-cell functions which are markedly reduced in senescence can be efficiently repaired by injection of synthetic thymosin-α1.
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UR - http://www.scopus.com/inward/citedby.url?scp=0020442841&partnerID=8YFLogxK
U2 - 10.1016/0008-8749(82)90487-7
DO - 10.1016/0008-8749(82)90487-7
M3 - Article
C2 - 6758954
AN - SCOPUS:0020442841
VL - 72
SP - 384
EP - 391
JO - Cellular Immunology
JF - Cellular Immunology
SN - 0008-8749
IS - 2
ER -