Recovery of synaptic transmission predicted from extracellular K+ undershoots following brief anoxia in hippocampal slices

Eugene L. Roberts; Thomas J. Sick

doi:10.1016/0006-8993(87)91064-X

Recovery of synaptic transmission predicted from extracellular K⁺ undershoots following brief anoxia in hippocampal slices

Eugene L. Roberts, Thomas J. Sick

Neurology

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

In rat hippocampal slices exposed to short duration anoxia, recovery of synaptic transmission was dependent upon the magnitude of the K⁺_o undershoot (K⁺_o drop below resting level) seen following return to normoxic conditions. Because the K⁺_o undershoot is likely to be related to ion pump activity, our results imply that recovery of brain from stroke depends upon how well ion transport and energy production recover.

Original language	English (US)
Pages (from-to)	178-181
Number of pages	4
Journal	Brain research
Volume	402
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(87)91064-X
State	Published - Jan 27 1987

Keywords

Hippocampal slice
Ion transport
K undershoot
Synaptic transmission

ASJC Scopus subject areas

Developmental Biology
Molecular Biology
Clinical Neurology
Neuroscience(all)

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abstract = "In rat hippocampal slices exposed to short duration anoxia, recovery of synaptic transmission was dependent upon the magnitude of the K+o undershoot (K+o drop below resting level) seen following return to normoxic conditions. Because the K+o undershoot is likely to be related to ion pump activity, our results imply that recovery of brain from stroke depends upon how well ion transport and energy production recover.",

keywords = "Hippocampal slice, Ion transport, K undershoot, Synaptic transmission",

author = "Roberts, {Eugene L.} and Sick, {Thomas J.}",

note = "Funding Information: These studies were supported in part by PHS Grants NS17949, NS05820 and NS07757.",

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AU - Sick, Thomas J.

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AB - In rat hippocampal slices exposed to short duration anoxia, recovery of synaptic transmission was dependent upon the magnitude of the K+o undershoot (K+o drop below resting level) seen following return to normoxic conditions. Because the K+o undershoot is likely to be related to ion pump activity, our results imply that recovery of brain from stroke depends upon how well ion transport and energy production recover.

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KW - K undershoot

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