TY - GEN
T1 - Recovery of metabolomic spectral sources using non-negative matrix factorization
AU - Du, Shuyan
AU - Sajda, Paul
AU - Stoyanova, Radka
AU - Brown, Truman R.
PY - 2005/12/1
Y1 - 2005/12/1
N2 - 1H magnetic resonance spectra (MRS) of biofluids contain rich biochemical information about the metabolic status of an organism. Through the application of pattern recognition and classification algorithms, such data have been shown to provide information for disease diagnosis as well as the effects of potential therapeutics. In this paper we describe a novel approach, using non-negative matrix factorization (NMF), for rapidly identifying metabolically meaningful spectral patterns in 1H MRS. We show that the intensities of these identified spectral patterns can be related to the onset of, and recovery from, toxicity in both a time-related and dose-related fashion. These patterns can be seen as a new type of biomarker for the biological effect under study. We demonstrate, using k-means clustering, that the recovered patterns can be used to characterize the metabolic status of the animal during the experiment.
AB - 1H magnetic resonance spectra (MRS) of biofluids contain rich biochemical information about the metabolic status of an organism. Through the application of pattern recognition and classification algorithms, such data have been shown to provide information for disease diagnosis as well as the effects of potential therapeutics. In this paper we describe a novel approach, using non-negative matrix factorization (NMF), for rapidly identifying metabolically meaningful spectral patterns in 1H MRS. We show that the intensities of these identified spectral patterns can be related to the onset of, and recovery from, toxicity in both a time-related and dose-related fashion. These patterns can be seen as a new type of biomarker for the biological effect under study. We demonstrate, using k-means clustering, that the recovered patterns can be used to characterize the metabolic status of the animal during the experiment.
UR - http://www.scopus.com/inward/record.url?scp=33846914206&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33846914206&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:33846914206
SN - 0780387406
SN - 9780780387409
T3 - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
SP - 1095
EP - 1098
BT - Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005
T2 - 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005
Y2 - 1 September 2005 through 4 September 2005
ER -