Recovery of metabolomic spectral sources using non-negative matrix factorization

Shuyan Du; Paul Sajda; Radka Stoyanova; Truman R. Brown

Recovery of metabolomic spectral sources using non-negative matrix factorization

Shuyan Du, Paul Sajda, Radka Stoyanova, Truman R. Brown

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

¹H magnetic resonance spectra (MRS) of biofluids contain rich biochemical information about the metabolic status of an organism. Through the application of pattern recognition and classification algorithms, such data have been shown to provide information for disease diagnosis as well as the effects of potential therapeutics. In this paper we describe a novel approach, using non-negative matrix factorization (NMF), for rapidly identifying metabolically meaningful spectral patterns in ¹H MRS. We show that the intensities of these identified spectral patterns can be related to the onset of, and recovery from, toxicity in both a time-related and dose-related fashion. These patterns can be seen as a new type of biomarker for the biological effect under study. We demonstrate, using k-means clustering, that the recovered patterns can be used to characterize the metabolic status of the animal during the experiment.

Original language	English (US)
Title of host publication	Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005
Pages	1095-1098
Number of pages	4
State	Published - Dec 1 2005
Externally published	Yes
Event	2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005 - Shanghai, China Duration: Sep 1 2005 → Sep 4 2005

Publication series

Name	Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume	7 VOLS
ISSN (Print)	0589-1019

Other

Other	2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005
Country	China
City	Shanghai
Period	9/1/05 → 9/4/05

ASJC Scopus subject areas

Signal Processing
Biomedical Engineering
Computer Vision and Pattern Recognition
Health Informatics

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Cite this

Du, S., Sajda, P., Stoyanova, R., & Brown, T. R. (2005). Recovery of metabolomic spectral sources using non-negative matrix factorization. In Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005 (pp. 1095-1098). [1616610] (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings; Vol. 7 VOLS).

Recovery of metabolomic spectral sources using non-negative matrix factorization. / Du, Shuyan; Sajda, Paul; Stoyanova, Radka; Brown, Truman R.

Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005. 2005. p. 1095-1098 1616610 (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings; Vol. 7 VOLS).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Du, S, Sajda, P, Stoyanova, R & Brown, TR 2005, Recovery of metabolomic spectral sources using non-negative matrix factorization. in Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005., 1616610, Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, vol. 7 VOLS, pp. 1095-1098, 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005, Shanghai, China, 9/1/05.

Du S, Sajda P, Stoyanova R, Brown TR. Recovery of metabolomic spectral sources using non-negative matrix factorization. In Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005. 2005. p. 1095-1098. 1616610. (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings).

Du, Shuyan ; Sajda, Paul ; Stoyanova, Radka ; Brown, Truman R. / Recovery of metabolomic spectral sources using non-negative matrix factorization. Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005. 2005. pp. 1095-1098 (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings).

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