Recovery of erythrocyte Li+/Na+ countertransport and choline transport from lithium therapy

Jared M. Diamond, Kay Meier, Lawrence F. Gosenfeld, Richard S. Jope, Donald J. Jenden, Suzette M. Wright

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Li+/Na+ countertransport, choline transport, and intracellular Li+ and choline were measured in the RBC of a manic-depressive subject as a function of time after termination of Li+ therapy. Countertransport recovered from its inhibition by Li+ in 10 days. This recovery involved a decrease in the Michaelis-Menten parameter Km, without change in Vmax. RBC choline decreased, and choline influx rose, much more slowly back towards pre-Li+ values over the course of two months. Thus, choline transport was still inhibited long after Li+ levels in RBC and plasma had become undetectable. Measurements on age-separated RBC fractions showed that recovery of choline transport was mainly in the young-cell fraction. Hence inhibition of choline transport by Li+ may be irreversible at the level of the individual RBC.

Original languageEnglish (US)
Pages (from-to)385-393
Number of pages9
JournalJournal of Psychiatric Research
Issue number4
StatePublished - 1982
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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