Recovery of erythrocyte Li+/Na+ countertransport and choline transport from lithium therapy

Jared M. Diamond, Kay Meier, Lawrence F. Gosenfeld, Richard S Jope, Donald J. Jenden, Suzette M. Wright

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Li+/Na+ countertransport, choline transport, and intracellular Li+ and choline were measured in the RBC of a manic-depressive subject as a function of time after termination of Li+ therapy. Countertransport recovered from its inhibition by Li+ in 10 days. This recovery involved a decrease in the Michaelis-Menten parameter Km, without change in Vmax. RBC choline decreased, and choline influx rose, much more slowly back towards pre-Li+ values over the course of two months. Thus, choline transport was still inhibited long after Li+ levels in RBC and plasma had become undetectable. Measurements on age-separated RBC fractions showed that recovery of choline transport was mainly in the young-cell fraction. Hence inhibition of choline transport by Li+ may be irreversible at the level of the individual RBC.

Original languageEnglish
Pages (from-to)385-393
Number of pages9
JournalJournal of Psychiatric Research
Volume17
Issue number4
DOIs
StatePublished - Jan 1 1982
Externally publishedYes

Fingerprint

Choline
Lithium
Erythrocytes
Therapeutics

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

Cite this

Recovery of erythrocyte Li+/Na+ countertransport and choline transport from lithium therapy. / Diamond, Jared M.; Meier, Kay; Gosenfeld, Lawrence F.; Jope, Richard S; Jenden, Donald J.; Wright, Suzette M.

In: Journal of Psychiatric Research, Vol. 17, No. 4, 01.01.1982, p. 385-393.

Research output: Contribution to journalArticle

Diamond, Jared M. ; Meier, Kay ; Gosenfeld, Lawrence F. ; Jope, Richard S ; Jenden, Donald J. ; Wright, Suzette M. / Recovery of erythrocyte Li+/Na+ countertransport and choline transport from lithium therapy. In: Journal of Psychiatric Research. 1982 ; Vol. 17, No. 4. pp. 385-393.
@article{14ef0d91b2a24ebfbf6d4fcdf8738d84,
title = "Recovery of erythrocyte Li+/Na+ countertransport and choline transport from lithium therapy",
abstract = "Li+/Na+ countertransport, choline transport, and intracellular Li+ and choline were measured in the RBC of a manic-depressive subject as a function of time after termination of Li+ therapy. Countertransport recovered from its inhibition by Li+ in 10 days. This recovery involved a decrease in the Michaelis-Menten parameter Km, without change in Vmax. RBC choline decreased, and choline influx rose, much more slowly back towards pre-Li+ values over the course of two months. Thus, choline transport was still inhibited long after Li+ levels in RBC and plasma had become undetectable. Measurements on age-separated RBC fractions showed that recovery of choline transport was mainly in the young-cell fraction. Hence inhibition of choline transport by Li+ may be irreversible at the level of the individual RBC.",
author = "Diamond, {Jared M.} and Kay Meier and Gosenfeld, {Lawrence F.} and Jope, {Richard S} and Jenden, {Donald J.} and Wright, {Suzette M.}",
year = "1982",
month = "1",
day = "1",
doi = "10.1016/0022-3956(82)90043-7",
language = "English",
volume = "17",
pages = "385--393",
journal = "Journal of Psychiatric Research",
issn = "0022-3956",
publisher = "Elsevier Limited",
number = "4",

}

TY - JOUR

T1 - Recovery of erythrocyte Li+/Na+ countertransport and choline transport from lithium therapy

AU - Diamond, Jared M.

AU - Meier, Kay

AU - Gosenfeld, Lawrence F.

AU - Jope, Richard S

AU - Jenden, Donald J.

AU - Wright, Suzette M.

PY - 1982/1/1

Y1 - 1982/1/1

N2 - Li+/Na+ countertransport, choline transport, and intracellular Li+ and choline were measured in the RBC of a manic-depressive subject as a function of time after termination of Li+ therapy. Countertransport recovered from its inhibition by Li+ in 10 days. This recovery involved a decrease in the Michaelis-Menten parameter Km, without change in Vmax. RBC choline decreased, and choline influx rose, much more slowly back towards pre-Li+ values over the course of two months. Thus, choline transport was still inhibited long after Li+ levels in RBC and plasma had become undetectable. Measurements on age-separated RBC fractions showed that recovery of choline transport was mainly in the young-cell fraction. Hence inhibition of choline transport by Li+ may be irreversible at the level of the individual RBC.

AB - Li+/Na+ countertransport, choline transport, and intracellular Li+ and choline were measured in the RBC of a manic-depressive subject as a function of time after termination of Li+ therapy. Countertransport recovered from its inhibition by Li+ in 10 days. This recovery involved a decrease in the Michaelis-Menten parameter Km, without change in Vmax. RBC choline decreased, and choline influx rose, much more slowly back towards pre-Li+ values over the course of two months. Thus, choline transport was still inhibited long after Li+ levels in RBC and plasma had become undetectable. Measurements on age-separated RBC fractions showed that recovery of choline transport was mainly in the young-cell fraction. Hence inhibition of choline transport by Li+ may be irreversible at the level of the individual RBC.

UR - http://www.scopus.com/inward/record.url?scp=0020430721&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020430721&partnerID=8YFLogxK

U2 - 10.1016/0022-3956(82)90043-7

DO - 10.1016/0022-3956(82)90043-7

M3 - Article

VL - 17

SP - 385

EP - 393

JO - Journal of Psychiatric Research

JF - Journal of Psychiatric Research

SN - 0022-3956

IS - 4

ER -