TY - JOUR
T1 - Recovery of Corneal Hysteresis After Reduction of Intraocular Pressure in Chronic Primary Angle-Closure Glaucoma
AU - Sun, Lei
AU - Shen, Meixiao
AU - Wang, Jianhua
AU - Fang, Aiwu
AU - Xu, Aiqin
AU - Fang, Haizhen
AU - Lu, Fan
N1 - Funding Information:
This study was supported by Research Grants from Chinese National Key Technologies R&D Program, Grant no. 2007BAI18B09, Beijing, China (Dr Lu) and Zhejiang Provincial Natural Science Foundation of China, Grants nos. R205739, Hangzhou, China (Dr Zhou) and Z205735 (Dr Lu). The authors indicate no financial conflict of interest. Involved in design and conduct of study (L.S., M.S., F.L., J.W.); collection, management, analysis, and interpretation of data (L.S., A.F., A.X., H.F.); and preparation, review, and approval of the manuscript (L.S., M.S., J.W., F.L.). This study was approved by the research review board at Wenzhou Medical College. Informed consent was obtained from each subject and each was treated in accordance with the tenets of the Declaration of Helsinki.
PY - 2009/6
Y1 - 2009/6
N2 - Purpose: To measure corneal hysteresis (CH) in unilateral chronic primary angle-closure glaucoma (CPACG) patients to determine if it was affected by high intraocular pressure (IOP). Design: Prospective interventional case series. Methods: CH and Goldmann-correlated IOP (IOPg) were obtained with the Ocular Response Analyzer (Reichert Ophthalmic Instruments, Dephew, New York, USA) and central corneal thickness (CCT) was measured by optical coherence tomography. Baseline CH, IOPg, and CCT were measured in 40 CPACG eyes and compared to the fellow eyes and 40 normal controls. Reduction of IOPg in CPACG eyes was achieved medically, followed by trabeculectomy and peripheral iridectomy. Measurements were repeated at 2 and 4 weeks posttherapy. Results: IOPg decreased significantly from 31.55 ± 10.48 mm Hg (mean ± standard deviation) before therapy to 11.47 ± 4.71 mm Hg, and CH increased significantly from 6.83 ± 2.08 mm Hg to 9.22 ± 1.80 mm Hg at 2 weeks, with no further changes after that. However, the CH in the treated eyes remained significantly lower compared with that of fellow and normal eyes. Before treatment, CH was negatively correlated with IOPg; however, there was no correlation after treatment. CCT was not affected by the reduced IOPg in the CPACG eyes. Conclusions: CH was significantly lower in CPACG patients, and partial recovery occurred after successful IOP-lowering therapy. Alternations affecting corneal biomechanical properties appear to occur during glaucoma development.
AB - Purpose: To measure corneal hysteresis (CH) in unilateral chronic primary angle-closure glaucoma (CPACG) patients to determine if it was affected by high intraocular pressure (IOP). Design: Prospective interventional case series. Methods: CH and Goldmann-correlated IOP (IOPg) were obtained with the Ocular Response Analyzer (Reichert Ophthalmic Instruments, Dephew, New York, USA) and central corneal thickness (CCT) was measured by optical coherence tomography. Baseline CH, IOPg, and CCT were measured in 40 CPACG eyes and compared to the fellow eyes and 40 normal controls. Reduction of IOPg in CPACG eyes was achieved medically, followed by trabeculectomy and peripheral iridectomy. Measurements were repeated at 2 and 4 weeks posttherapy. Results: IOPg decreased significantly from 31.55 ± 10.48 mm Hg (mean ± standard deviation) before therapy to 11.47 ± 4.71 mm Hg, and CH increased significantly from 6.83 ± 2.08 mm Hg to 9.22 ± 1.80 mm Hg at 2 weeks, with no further changes after that. However, the CH in the treated eyes remained significantly lower compared with that of fellow and normal eyes. Before treatment, CH was negatively correlated with IOPg; however, there was no correlation after treatment. CCT was not affected by the reduced IOPg in the CPACG eyes. Conclusions: CH was significantly lower in CPACG patients, and partial recovery occurred after successful IOP-lowering therapy. Alternations affecting corneal biomechanical properties appear to occur during glaucoma development.
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U2 - 10.1016/j.ajo.2009.01.008
DO - 10.1016/j.ajo.2009.01.008
M3 - Article
C2 - 19327738
AN - SCOPUS:67349134656
VL - 147
SP - 1061-1066.e2
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
SN - 0002-9394
IS - 6
ER -