Abstract
The antibiotic 2'-deoxycoformycin, a potent inhibitor of adenosine deaminase, has potential as a chemotherapeutic agent. Injection of 2'-deoxycoformycin i.v. (0.2 mg/kg) to mice bearing ascites L1210 leukemia cells completely inhibits adenosine deaminase in both erythrocytes and L1210 cells. The recovery of the enzymic activity is markedly different in the two tissues. The recovery is very slow in erythrocytes (13% in 48 hr), whereas 80% recovery occurs during the same time interval in L1210 cells. This marked difference in the recovery of the enzyme in different tissues may play a role in the pharmacological and chemotherapeutic behavior of this drug.
| Original language | English |
|---|---|
| Pages (from-to) | 1425-1427 |
| Number of pages | 3 |
| Journal | Cancer Research |
| Volume | 39 |
| Issue number | 4 |
| State | Published - Dec 1 1979 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cancer Research
- Oncology
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Recovery of 2'-deoxycoformycin-inhibited adenosine deaminase of mouse erythrocytes and leukemia L1210 in vivo. / Agarwal, R. P.
In: Cancer Research, Vol. 39, No. 4, 01.12.1979, p. 1425-1427.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Recovery of 2'-deoxycoformycin-inhibited adenosine deaminase of mouse erythrocytes and leukemia L1210 in vivo
AU - Agarwal, R. P.
PY - 1979/12/1
Y1 - 1979/12/1
N2 - The antibiotic 2'-deoxycoformycin, a potent inhibitor of adenosine deaminase, has potential as a chemotherapeutic agent. Injection of 2'-deoxycoformycin i.v. (0.2 mg/kg) to mice bearing ascites L1210 leukemia cells completely inhibits adenosine deaminase in both erythrocytes and L1210 cells. The recovery of the enzymic activity is markedly different in the two tissues. The recovery is very slow in erythrocytes (13% in 48 hr), whereas 80% recovery occurs during the same time interval in L1210 cells. This marked difference in the recovery of the enzyme in different tissues may play a role in the pharmacological and chemotherapeutic behavior of this drug.
AB - The antibiotic 2'-deoxycoformycin, a potent inhibitor of adenosine deaminase, has potential as a chemotherapeutic agent. Injection of 2'-deoxycoformycin i.v. (0.2 mg/kg) to mice bearing ascites L1210 leukemia cells completely inhibits adenosine deaminase in both erythrocytes and L1210 cells. The recovery of the enzymic activity is markedly different in the two tissues. The recovery is very slow in erythrocytes (13% in 48 hr), whereas 80% recovery occurs during the same time interval in L1210 cells. This marked difference in the recovery of the enzyme in different tissues may play a role in the pharmacological and chemotherapeutic behavior of this drug.
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UR - http://www.scopus.com/inward/citedby.url?scp=0018773513&partnerID=8YFLogxK
M3 - Article
C2 - 421226
AN - SCOPUS:0018773513
VL - 39
SP - 1425
EP - 1427
JO - Journal of Cancer Research
JF - Journal of Cancer Research
SN - 0099-7013
IS - 4
ER -