Recovery of 2'-deoxycoformycin-inhibited adenosine deaminase of mouse erythrocytes and leukemia L1210 in vivo

R. P. Agarwal

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The antibiotic 2'-deoxycoformycin, a potent inhibitor of adenosine deaminase, has potential as a chemotherapeutic agent. Injection of 2'-deoxycoformycin i.v. (0.2 mg/kg) to mice bearing ascites L1210 leukemia cells completely inhibits adenosine deaminase in both erythrocytes and L1210 cells. The recovery of the enzymic activity is markedly different in the two tissues. The recovery is very slow in erythrocytes (13% in 48 hr), whereas 80% recovery occurs during the same time interval in L1210 cells. This marked difference in the recovery of the enzyme in different tissues may play a role in the pharmacological and chemotherapeutic behavior of this drug.

Original languageEnglish
Pages (from-to)1425-1427
Number of pages3
JournalCancer Research
Volume39
Issue number4
StatePublished - Dec 1 1979
Externally publishedYes

Fingerprint

Pentostatin
Leukemia L1210
Erythrocytes
Adenosine Deaminase Inhibitors
Adenosine Deaminase
Ascites
Pharmacology
Anti-Bacterial Agents
Injections
Enzymes
Pharmaceutical Preparations
Mouse Ada protein

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Recovery of 2'-deoxycoformycin-inhibited adenosine deaminase of mouse erythrocytes and leukemia L1210 in vivo. / Agarwal, R. P.

In: Cancer Research, Vol. 39, No. 4, 01.12.1979, p. 1425-1427.

Research output: Contribution to journalArticle

@article{5ef523eed61b4e5da11018ad4cb18b40,
title = "Recovery of 2'-deoxycoformycin-inhibited adenosine deaminase of mouse erythrocytes and leukemia L1210 in vivo",
abstract = "The antibiotic 2'-deoxycoformycin, a potent inhibitor of adenosine deaminase, has potential as a chemotherapeutic agent. Injection of 2'-deoxycoformycin i.v. (0.2 mg/kg) to mice bearing ascites L1210 leukemia cells completely inhibits adenosine deaminase in both erythrocytes and L1210 cells. The recovery of the enzymic activity is markedly different in the two tissues. The recovery is very slow in erythrocytes (13{\%} in 48 hr), whereas 80{\%} recovery occurs during the same time interval in L1210 cells. This marked difference in the recovery of the enzyme in different tissues may play a role in the pharmacological and chemotherapeutic behavior of this drug.",
author = "Agarwal, {R. P.}",
year = "1979",
month = "12",
day = "1",
language = "English",
volume = "39",
pages = "1425--1427",
journal = "Journal of Cancer Research",
issn = "0099-7013",
publisher = "American Association for Cancer Research Inc.",
number = "4",

}

TY - JOUR

T1 - Recovery of 2'-deoxycoformycin-inhibited adenosine deaminase of mouse erythrocytes and leukemia L1210 in vivo

AU - Agarwal, R. P.

PY - 1979/12/1

Y1 - 1979/12/1

N2 - The antibiotic 2'-deoxycoformycin, a potent inhibitor of adenosine deaminase, has potential as a chemotherapeutic agent. Injection of 2'-deoxycoformycin i.v. (0.2 mg/kg) to mice bearing ascites L1210 leukemia cells completely inhibits adenosine deaminase in both erythrocytes and L1210 cells. The recovery of the enzymic activity is markedly different in the two tissues. The recovery is very slow in erythrocytes (13% in 48 hr), whereas 80% recovery occurs during the same time interval in L1210 cells. This marked difference in the recovery of the enzyme in different tissues may play a role in the pharmacological and chemotherapeutic behavior of this drug.

AB - The antibiotic 2'-deoxycoformycin, a potent inhibitor of adenosine deaminase, has potential as a chemotherapeutic agent. Injection of 2'-deoxycoformycin i.v. (0.2 mg/kg) to mice bearing ascites L1210 leukemia cells completely inhibits adenosine deaminase in both erythrocytes and L1210 cells. The recovery of the enzymic activity is markedly different in the two tissues. The recovery is very slow in erythrocytes (13% in 48 hr), whereas 80% recovery occurs during the same time interval in L1210 cells. This marked difference in the recovery of the enzyme in different tissues may play a role in the pharmacological and chemotherapeutic behavior of this drug.

UR - http://www.scopus.com/inward/record.url?scp=0018773513&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018773513&partnerID=8YFLogxK

M3 - Article

C2 - 421226

AN - SCOPUS:0018773513

VL - 39

SP - 1425

EP - 1427

JO - Journal of Cancer Research

JF - Journal of Cancer Research

SN - 0099-7013

IS - 4

ER -