Recovery from Proactive Semantic Interference and MRI Volume: A Replication and Extension Study

David Loewenstein, Rosie Curiel Cid, Steven DeKosky, Monica Rosselli, Russell Bauer, Maria Grieg-Custo, Ailyn Penate, Chunfei Li, Gabriel Lizagarra, Todd Golde, Malek Adjouadi, Ranjan Duara

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: The rise in incidence of Alzheimer's disease (AD) has led to efforts to advance early detection of the disease during its preclinical stages. To achieve this, the field needs to develop more sensitive cognitive tests that relate to biological markers of disease pathology. Failure to recover from proactive interference (frPSI) is one such cognitive marker that is associated with volumetric reductions in the hippocampus, precuneus, and other AD-prone regions, and to amyloid load in the brain. Objective: The current study attempted to replicate and extend our previous findings that frPSI is a sensitive marker of early AD, and related to a unique pattern of volumetric loss in AD prone areas. Methods: Three different memory measures were examined relative to volumetric loss and cortical thickness among 45 participants with amnestic mild cognitive impairment. Results: frPSI was uniquely associated with reduced volumes in the hippocampus (r=0.50) precuneus (r=0.41), and other AD prone regions, replicating previous findings. Strong associations between frPSI and lower entorhinal cortex volumes and cortical thickness (r≥0.60) and precuneus (r=0.50) were also observed. Conclusion: Unique and strong associations between volumetric reductions and frPSI as observed by Loewenstein and colleagues were replicated. Together with cortical thickness findings, these results indicate that frPSI is worthy of further study as a sensitive and early cognitive marker of AD.

Original languageEnglish (US)
Pages (from-to)131-139
Number of pages9
JournalJournal of Alzheimer's Disease
Volume59
Issue number1
DOIs
StatePublished - 2017

Fingerprint

Semantics
Alzheimer Disease
Parietal Lobe
Hippocampus
Entorhinal Cortex
Amyloid
Early Diagnosis
Biomarkers
Pathology
Incidence
Brain

Keywords

  • Cortical thickness
  • LASSI-L
  • mild cognitive impairment
  • MRI volume
  • proactive semantic interference

ASJC Scopus subject areas

  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Recovery from Proactive Semantic Interference and MRI Volume : A Replication and Extension Study. / Loewenstein, David; Curiel Cid, Rosie; DeKosky, Steven; Rosselli, Monica; Bauer, Russell; Grieg-Custo, Maria; Penate, Ailyn; Li, Chunfei; Lizagarra, Gabriel; Golde, Todd; Adjouadi, Malek; Duara, Ranjan.

In: Journal of Alzheimer's Disease, Vol. 59, No. 1, 2017, p. 131-139.

Research output: Contribution to journalArticle

Loewenstein, D, Curiel Cid, R, DeKosky, S, Rosselli, M, Bauer, R, Grieg-Custo, M, Penate, A, Li, C, Lizagarra, G, Golde, T, Adjouadi, M & Duara, R 2017, 'Recovery from Proactive Semantic Interference and MRI Volume: A Replication and Extension Study', Journal of Alzheimer's Disease, vol. 59, no. 1, pp. 131-139. https://doi.org/10.3233/JAD-170276
Loewenstein, David ; Curiel Cid, Rosie ; DeKosky, Steven ; Rosselli, Monica ; Bauer, Russell ; Grieg-Custo, Maria ; Penate, Ailyn ; Li, Chunfei ; Lizagarra, Gabriel ; Golde, Todd ; Adjouadi, Malek ; Duara, Ranjan. / Recovery from Proactive Semantic Interference and MRI Volume : A Replication and Extension Study. In: Journal of Alzheimer's Disease. 2017 ; Vol. 59, No. 1. pp. 131-139.
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