Reconstitution of T cell functions in aging mice by thymosin α1

Daniela Frasca, Luciano Adorini, Camillo Mancini, Gino Doria

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Helper T cell activity of spleen cells from BDF1 mice is impaired by aging but is restored to a large extent by injection of thymosin α1, a synthetic peptide consisting of 28 amino acid residues. Injection of an equimolar amount of the N14 (N-terminal half of thymosin α1) synthetic fragment is at least as effective as the entire α1 molecule in increasing helper T cell activity of spleen cells from old (6-18 months) mice but not from young (3 months) mice. Conversely, injection of the C14 (C-terminal half of thymosin α1) synthetic fragment is devoid of any effect in both young and old mice. Since helper T cell activity of spleen cells from old mice is also increased by injection of interleukin-2, the observed enhancement of interleukin-2 production by mitogen-activated spleen cells from old mice upon injection of thymosin α1 or the N14 fragment suggests that these peptides amplify helper T cell activity by increasing the cell precursor frequency of interleukin-2-producing T cells. This conclusion is further supported by the finding that injection of thymosin α1, or its N14, but not C14, fragment enhances the expression of interleukin-2 receptors on mitogen-activated spleen cells from old but not from young mice.

Original languageEnglish
Pages (from-to)155-163
Number of pages9
JournalImmunopharmacology
Volume11
Issue number3
DOIs
StatePublished - Jan 1 1986
Externally publishedYes

Fingerprint

Thymosin
T-Lymphocytes
Helper-Inducer T-Lymphocytes
Spleen
Injections
Interleukin-2
Mitogens
Peptide Fragments
Interleukin-2 Receptors
Amino Acids
Peptides

Keywords

  • Aging
  • Helper activity
  • Interleukin-2 production
  • Interleukin-2 receptor
  • Thymic factors

ASJC Scopus subject areas

  • Pharmacology

Cite this

Reconstitution of T cell functions in aging mice by thymosin α1. / Frasca, Daniela; Adorini, Luciano; Mancini, Camillo; Doria, Gino.

In: Immunopharmacology, Vol. 11, No. 3, 01.01.1986, p. 155-163.

Research output: Contribution to journalArticle

Frasca, Daniela ; Adorini, Luciano ; Mancini, Camillo ; Doria, Gino. / Reconstitution of T cell functions in aging mice by thymosin α1. In: Immunopharmacology. 1986 ; Vol. 11, No. 3. pp. 155-163.
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