Recombinant Staphylococcus aureus exfoliative toxins are not bacterial superantigens

Lisa R W Plano, Delia M. Gutman, Markus Woischnik, Carleen M. Collins

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Staphylococcal scalded-skin syndrome is an exfoliative dermatitis characterized by the separation of the epidermis at the stratum granulosum. This disruption is mediated by one of two Staphylococcus aureus exotoxins, exfoliative toxins A and B (ETA and ETB). Both ETA and ETB have been reported to be bacterial superantigens. A controversy exists, however, as other data indicate that these exotoxins are not superantigens. Here we demonstrate that recombinant exfoliative toxins produced in Escherichia coli do not act as T- cell mitogens and thus are not bacterial superantigens. These data fit the clinical profile of the disease, which is not associated with the classic symptoms of a superantigen-mediated syndrome.

Original languageEnglish
Pages (from-to)3048-3052
Number of pages5
JournalInfection and Immunity
Volume68
Issue number5
DOIs
StatePublished - May 1 2000

Fingerprint

Exfoliatins
Superantigens
Staphylococcus aureus
Exotoxins
Staphylococcal Scalded Skin Syndrome
Exfoliative Dermatitis
Mitogens
Epidermis
Escherichia coli
T-Lymphocytes

ASJC Scopus subject areas

  • Immunology

Cite this

Recombinant Staphylococcus aureus exfoliative toxins are not bacterial superantigens. / Plano, Lisa R W; Gutman, Delia M.; Woischnik, Markus; Collins, Carleen M.

In: Infection and Immunity, Vol. 68, No. 5, 01.05.2000, p. 3048-3052.

Research output: Contribution to journalArticle

Plano, Lisa R W ; Gutman, Delia M. ; Woischnik, Markus ; Collins, Carleen M. / Recombinant Staphylococcus aureus exfoliative toxins are not bacterial superantigens. In: Infection and Immunity. 2000 ; Vol. 68, No. 5. pp. 3048-3052.
@article{02ff9e377f4a457b97dd32328b3113ee,
title = "Recombinant Staphylococcus aureus exfoliative toxins are not bacterial superantigens",
abstract = "Staphylococcal scalded-skin syndrome is an exfoliative dermatitis characterized by the separation of the epidermis at the stratum granulosum. This disruption is mediated by one of two Staphylococcus aureus exotoxins, exfoliative toxins A and B (ETA and ETB). Both ETA and ETB have been reported to be bacterial superantigens. A controversy exists, however, as other data indicate that these exotoxins are not superantigens. Here we demonstrate that recombinant exfoliative toxins produced in Escherichia coli do not act as T- cell mitogens and thus are not bacterial superantigens. These data fit the clinical profile of the disease, which is not associated with the classic symptoms of a superantigen-mediated syndrome.",
author = "Plano, {Lisa R W} and Gutman, {Delia M.} and Markus Woischnik and Collins, {Carleen M.}",
year = "2000",
month = "5",
day = "1",
doi = "10.1128/IAI.68.5.3048-3052.2000",
language = "English",
volume = "68",
pages = "3048--3052",
journal = "Infection and Immunity",
issn = "0019-9567",
publisher = "American Society for Microbiology",
number = "5",

}

TY - JOUR

T1 - Recombinant Staphylococcus aureus exfoliative toxins are not bacterial superantigens

AU - Plano, Lisa R W

AU - Gutman, Delia M.

AU - Woischnik, Markus

AU - Collins, Carleen M.

PY - 2000/5/1

Y1 - 2000/5/1

N2 - Staphylococcal scalded-skin syndrome is an exfoliative dermatitis characterized by the separation of the epidermis at the stratum granulosum. This disruption is mediated by one of two Staphylococcus aureus exotoxins, exfoliative toxins A and B (ETA and ETB). Both ETA and ETB have been reported to be bacterial superantigens. A controversy exists, however, as other data indicate that these exotoxins are not superantigens. Here we demonstrate that recombinant exfoliative toxins produced in Escherichia coli do not act as T- cell mitogens and thus are not bacterial superantigens. These data fit the clinical profile of the disease, which is not associated with the classic symptoms of a superantigen-mediated syndrome.

AB - Staphylococcal scalded-skin syndrome is an exfoliative dermatitis characterized by the separation of the epidermis at the stratum granulosum. This disruption is mediated by one of two Staphylococcus aureus exotoxins, exfoliative toxins A and B (ETA and ETB). Both ETA and ETB have been reported to be bacterial superantigens. A controversy exists, however, as other data indicate that these exotoxins are not superantigens. Here we demonstrate that recombinant exfoliative toxins produced in Escherichia coli do not act as T- cell mitogens and thus are not bacterial superantigens. These data fit the clinical profile of the disease, which is not associated with the classic symptoms of a superantigen-mediated syndrome.

UR - http://www.scopus.com/inward/record.url?scp=0034071181&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034071181&partnerID=8YFLogxK

U2 - 10.1128/IAI.68.5.3048-3052.2000

DO - 10.1128/IAI.68.5.3048-3052.2000

M3 - Article

C2 - 10769013

AN - SCOPUS:0034071181

VL - 68

SP - 3048

EP - 3052

JO - Infection and Immunity

JF - Infection and Immunity

SN - 0019-9567

IS - 5

ER -