Recombinant Staphylococcus aureus exfoliative toxins are not bacterial superantigens

Lisa R.W. Plano, Delia M. Gutman, Markus Woischnik, Carleen M. Collins

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Staphylococcal scalded-skin syndrome is an exfoliative dermatitis characterized by the separation of the epidermis at the stratum granulosum. This disruption is mediated by one of two Staphylococcus aureus exotoxins, exfoliative toxins A and B (ETA and ETB). Both ETA and ETB have been reported to be bacterial superantigens. A controversy exists, however, as other data indicate that these exotoxins are not superantigens. Here we demonstrate that recombinant exfoliative toxins produced in Escherichia coli do not act as T- cell mitogens and thus are not bacterial superantigens. These data fit the clinical profile of the disease, which is not associated with the classic symptoms of a superantigen-mediated syndrome.

Original languageEnglish (US)
Pages (from-to)3048-3052
Number of pages5
JournalInfection and immunity
Volume68
Issue number5
DOIs
StatePublished - May 2000

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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