Recombinant protein-co-PEG hydrogels as synthetic extracellular matrices for tissue regeneration

S. C. Rizzi, S. Halstenberg, H. G. Schmökel, F. E. Weber, J. A. Hubbell

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The use of recombinant protein-co-poly(ehtylene glycol) (PEG)hydrogel as synthetic extracellular matrices for tissue regeneration was studied. The hydrogels were tested as provisional carriers for non-convalently entrapped rhBMP-2. Biochemical assays of hydrogels formed from PEG6000 divinyl sulfone and degradable protein polymers showed a rapid increase of swelling upon gel dissolution indicating bulk degradation of networks MMP-1. On the other hand, non-degradable hydrogels were found to remain stable upon exposure of MMP-1.

Original languageEnglish
Title of host publicationTransactions - 7th World Biomaterials Congress
StatePublished - Dec 1 2004
Externally publishedYes
EventTransactions - 7th World Biomaterials Congress - Sydney, Australia
Duration: May 17 2004May 21 2004

Other

OtherTransactions - 7th World Biomaterials Congress
CountryAustralia
CitySydney
Period5/17/045/21/04

Fingerprint

Recombinant proteins
Tissue regeneration
Hydrogels
Polyethylene glycols
Glycols
Swelling
Assays
Dissolution
Gels
Proteins
Degradation
Polymers

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Rizzi, S. C., Halstenberg, S., Schmökel, H. G., Weber, F. E., & Hubbell, J. A. (2004). Recombinant protein-co-PEG hydrogels as synthetic extracellular matrices for tissue regeneration. In Transactions - 7th World Biomaterials Congress

Recombinant protein-co-PEG hydrogels as synthetic extracellular matrices for tissue regeneration. / Rizzi, S. C.; Halstenberg, S.; Schmökel, H. G.; Weber, F. E.; Hubbell, J. A.

Transactions - 7th World Biomaterials Congress. 2004.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Rizzi, SC, Halstenberg, S, Schmökel, HG, Weber, FE & Hubbell, JA 2004, Recombinant protein-co-PEG hydrogels as synthetic extracellular matrices for tissue regeneration. in Transactions - 7th World Biomaterials Congress. Transactions - 7th World Biomaterials Congress, Sydney, Australia, 5/17/04.
Rizzi SC, Halstenberg S, Schmökel HG, Weber FE, Hubbell JA. Recombinant protein-co-PEG hydrogels as synthetic extracellular matrices for tissue regeneration. In Transactions - 7th World Biomaterials Congress. 2004
Rizzi, S. C. ; Halstenberg, S. ; Schmökel, H. G. ; Weber, F. E. ; Hubbell, J. A. / Recombinant protein-co-PEG hydrogels as synthetic extracellular matrices for tissue regeneration. Transactions - 7th World Biomaterials Congress. 2004.
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