Recombinant protein-co-PEG hydrogels as synthetic extracellular matrices for tissue regeneration

S. C. Rizzi, S. Halstenberg, H. G. Schmökel, F. E. Weber, J. A. Hubbell

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The use of recombinant protein-co-poly(ehtylene glycol) (PEG)hydrogel as synthetic extracellular matrices for tissue regeneration was studied. The hydrogels were tested as provisional carriers for non-convalently entrapped rhBMP-2. Biochemical assays of hydrogels formed from PEG6000 divinyl sulfone and degradable protein polymers showed a rapid increase of swelling upon gel dissolution indicating bulk degradation of networks MMP-1. On the other hand, non-degradable hydrogels were found to remain stable upon exposure of MMP-1.

Original languageEnglish (US)
Title of host publicationTransactions - 7th World Biomaterials Congress
Number of pages1
StatePublished - Dec 1 2004
EventTransactions - 7th World Biomaterials Congress - Sydney, Australia
Duration: May 17 2004May 21 2004

Publication series

NameTransactions - 7th World Biomaterials Congress

Other

OtherTransactions - 7th World Biomaterials Congress
CountryAustralia
CitySydney
Period5/17/045/21/04

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    Rizzi, S. C., Halstenberg, S., Schmökel, H. G., Weber, F. E., & Hubbell, J. A. (2004). Recombinant protein-co-PEG hydrogels as synthetic extracellular matrices for tissue regeneration. In Transactions - 7th World Biomaterials Congress (Transactions - 7th World Biomaterials Congress).