Recombinant human platelet-derived growth factor for refractory nondiabetic ulcers: A retrospective series

Catherine Harrison-Balestra, William H. Eaglstein, Anna F. Falabela, Robert S. Kirsner

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

BACKGROUND. Recombinant human platelet-derived growth factor-BB (rhPDGF-BB or rhPDGF gel 0.01%) has been approved by the U.S. Food and Drug Administration (FDA) for topical use on lower extremity, neuropathic, diabetic ulcers to enhance healing and has been reported to be effective in expediting the healing of full-thickness chronic pressure ulcers. Published clinical data using rhPDGF gel to treat nondiabetic and nonpressure-related ulcers have been limited. OBJECTIVE. To determine the effectiveness of topical rhPDGF gel in treating refractory chronic ulcers other than diabetic, neuropathic ulcers. METHODS. A retrospective chart review was performed on patients without diabetes mellitus-related ulcers treated with topical rhPDGF gel 0.01%. RESULTS. Twelve patients with 14 ulcers were treated. Nine of 14 ulcers healed (64%) with a mean time to healing of 26 weeks. Two of the nine healed ulcers (22%) reopened during a 15-month follow-up period. CONCLUSION. rhPDGF gel is an effective and well-tolerated treatment for refractory chronic ulcers.

Original languageEnglish (US)
Pages (from-to)755-760
Number of pages6
JournalDermatologic Surgery
Volume28
Issue number8
DOIs
StatePublished - Aug 1 2002

ASJC Scopus subject areas

  • Surgery
  • Dermatology

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