Reciprocal interactions between the GH axis and sleep

Eve Van Cauter, Federica Latta, Arlet Nedeltcheva, Karine Spiegel, Rachel Leproult, Claire Vandenbril, Roy E Weiss, Jean Mockel, Jean Jacques Legros, Georges Copinschi

Research output: Contribution to journalArticle

99 Citations (Scopus)

Abstract

For more than 30 years, growth hormone (GH) has been observed to be preferentially secreted during deep, slow-wave sleep (SWS). However, the mechanisms that underlie this robust relationship that links anabolic processes in the body with behavioral rest and decreased cerebral metabolism remain to be elucidated. Current evidence indicates that GH secretion during the beginning of sleep appears to be primarily regulated by GH-releasing hormone (GHRH) stimulation occurring during a period of relative somatostatin withdrawal, which also is associated with elevated levels of circulating ghrelin. Apparently, two populations of GHRH neurons need to be simultaneously active to stimulate, in a coordinated fashion, SWS and pituitary GH release. Pharmacological interventions that are capable of increasing the duration and/or the intensity of SWS such as oral administration of γ-hydroxybutyrate (GHB), also increase the rate of GH release. Because the normal negative feedback exerted by GH on central GHRH is inoperative in patients with GH deficiency, it is possible that the decreased energy levels and fatigue often reported by GH-deficient adults partly reflect an alteration in sleep-wake regulation. Preliminary data from a sleep study of adults with GH deficiency using wrist actigraphy for 6 nights at home and polysomnography in the laboratory indeed show decreased total sleep time and increased sleep fragmentation in GH-deficient patients as compared with normal controls.

Original languageEnglish (US)
JournalGrowth Hormone and IGF Research
Volume14
Issue numberSUPPL. A
StatePublished - Jun 2004
Externally publishedYes

Fingerprint

Growth Hormone
Sleep
Hormones
Actigraphy
Hydroxybutyrates
Growth Hormone-Releasing Hormone
Ghrelin
Sleep Deprivation
Polysomnography
Somatostatin
Wrist
Fatigue
Oral Administration
Pharmacology
Neurons
Population

Keywords

  • Growth hormone
  • Growth hormone deficiency
  • Polysomnography
  • Slow-wave sleep

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Van Cauter, E., Latta, F., Nedeltcheva, A., Spiegel, K., Leproult, R., Vandenbril, C., ... Copinschi, G. (2004). Reciprocal interactions between the GH axis and sleep. Growth Hormone and IGF Research, 14(SUPPL. A).

Reciprocal interactions between the GH axis and sleep. / Van Cauter, Eve; Latta, Federica; Nedeltcheva, Arlet; Spiegel, Karine; Leproult, Rachel; Vandenbril, Claire; Weiss, Roy E; Mockel, Jean; Legros, Jean Jacques; Copinschi, Georges.

In: Growth Hormone and IGF Research, Vol. 14, No. SUPPL. A, 06.2004.

Research output: Contribution to journalArticle

Van Cauter, E, Latta, F, Nedeltcheva, A, Spiegel, K, Leproult, R, Vandenbril, C, Weiss, RE, Mockel, J, Legros, JJ & Copinschi, G 2004, 'Reciprocal interactions between the GH axis and sleep', Growth Hormone and IGF Research, vol. 14, no. SUPPL. A.
Van Cauter E, Latta F, Nedeltcheva A, Spiegel K, Leproult R, Vandenbril C et al. Reciprocal interactions between the GH axis and sleep. Growth Hormone and IGF Research. 2004 Jun;14(SUPPL. A).
Van Cauter, Eve ; Latta, Federica ; Nedeltcheva, Arlet ; Spiegel, Karine ; Leproult, Rachel ; Vandenbril, Claire ; Weiss, Roy E ; Mockel, Jean ; Legros, Jean Jacques ; Copinschi, Georges. / Reciprocal interactions between the GH axis and sleep. In: Growth Hormone and IGF Research. 2004 ; Vol. 14, No. SUPPL. A.
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