Receptor binding and antinociceptive properties of phencyclidine opiate-like derivatives

Yossef Itzhak, Asher Kalir, Ben Avi Weissman, Cohen Sasson

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The relative potencies of a new series of phencyclidine (PCP) analogs for the displacement of [3H]morphine binding from rat brain homogenates are well correlated with the relative antinociceptive potencies in the test of writhing induced by acetic acid (0.6%). One group of compoundss exerts a completely naloxone-reversible analgesic effect, while the effects of a second group are only partially reversed by naloxone. These findings and the structural differences between the two groups suggest that their analgesic activity is mediated through different opiate receptors. opiate receptors.

Original languageEnglish
Pages (from-to)305-311
Number of pages7
JournalEuropean Journal of Pharmacology
Volume72
Issue number4
DOIs
StatePublished - Jul 10 1981
Externally publishedYes

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Opiate Alkaloids
Phencyclidine
Opioid Receptors
Naloxone
Analgesics
Acetic Acid
Morphine
Brain

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Receptor binding and antinociceptive properties of phencyclidine opiate-like derivatives. / Itzhak, Yossef; Kalir, Asher; Weissman, Ben Avi; Sasson, Cohen.

In: European Journal of Pharmacology, Vol. 72, No. 4, 10.07.1981, p. 305-311.

Research output: Contribution to journalArticle

Itzhak, Yossef ; Kalir, Asher ; Weissman, Ben Avi ; Sasson, Cohen. / Receptor binding and antinociceptive properties of phencyclidine opiate-like derivatives. In: European Journal of Pharmacology. 1981 ; Vol. 72, No. 4. pp. 305-311.
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