Recent treatment modalities for cardiovascular diseases with a focus on stem cells, aptamers, exosomes and nanomedicine

Rahul Mittal, Vasanti M. Jhaveri, Hannah S. McMurry, Sae In Samantha Kay, Kyle J. Sutherland, Lin Nicole, Jeenu Mittal, Rahul Dev Jayant

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide. Due to the significant impact of CVD on humans, there is a need to develop novel treatment modalities tailored to major classes of cardiac diseases including hypertension, coronary artery disease, cardiomyopathies, arrhythmias, valvular disease and inflammatory diseases. In this article, we discuss recent advancements regarding development of therapeutic strategies based on stem cells, aptamers, exosomes, drug-eluting and dissolvable stents, immunotherapy and nanomedicine for the treatment of CVD. We summarize current research and clinical advances in cardiovascular therapeutics, with a focus on therapies that move beyond current oral- or sublingual-based regimens. This review article provides insight into current research and future treatment strategies that hold a great relevance for future clinical practice in pursuit of improving quality of life of patients suffering from CVD.

Original languageEnglish (US)
Pages (from-to)831-840
Number of pages10
JournalArtificial Cells, Nanomedicine and Biotechnology
Volume46
Issue numbersup1
DOIs
StatePublished - Oct 31 2018

Keywords

  • aptamers
  • Cardiovascular diseases
  • exosomes
  • immunotherapy
  • nanomedicine
  • stem cells
  • treatment modalities

ASJC Scopus subject areas

  • Biotechnology
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Pharmaceutical Science

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