Recent developments in hirschsprung's-associated enterocolitis

Elizabeth M. Pontarelli, Henri R. Ford, Christopher P. Gayer

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Hirschsprung's-associated enterocolitis (HAEC) continues to be a significant source of morbidity for patients with Hirschsprung's disease (HD).New clinical and histologic classification systems for HAEC will improve consistency between reports and increase the ability to compare outcomes. A complete understanding of disease pathogenesis is lacking, but evidence suggests that the intestinal microbiota may play a role in the development of HD and HAEC. The benefits of adjunctive therapies, such as anal dilations and botulinum toxin to reduce the incidence of HAEC following corrective endorectal pull-through, remain controversial. Finally, new clinical data have identified an association between HAEC and inflammatory bowel disease and will likely lead to further genetic studies to elucidate the connection between these two disease processes.

Original languageEnglish (US)
Article number340
JournalCurrent gastroenterology reports
Issue number8
StatePublished - Aug 2013
Externally publishedYes


  • Dilation
  • Enterocolitis
  • Hirschsprung's disease
  • Inflammatory bowel disease
  • Microbiota

ASJC Scopus subject areas

  • Gastroenterology


Dive into the research topics of 'Recent developments in hirschsprung's-associated enterocolitis'. Together they form a unique fingerprint.

Cite this