Recent Development of Cardiac Troponin i Detection

Xu Han, Shanghao Li, Zhili Peng, Abdelhameed M. Othman, Roger Leblanc

Research output: Contribution to journalReview articlepeer-review

57 Scopus citations

Abstract

Cardiovascular disease (CVD) has threatened human lives for decades, and a technique for estimating and healing is still needed. There has been increasing interest in finding CVD diagnostic biomarkers to predict risk. Cardiac troponin I (cTnI) has proven to be a significant biomarker for acute myocardial infarction detection. An immunoassay based biosensor for cTnI can play an important role in diagnosis of CVD. Over the past decades, various methodologies regarding cTnI detection have been studied, including colorimetric, fluorescence, paramagnetic, electrochemical, and surface plasmon resonance. This review will focus more on recent strategies about surface immobilized cTnI detection.

Original languageEnglish (US)
Pages (from-to)106-114
Number of pages9
JournalACS Sensors
Volume1
Issue number2
DOIs
StatePublished - Feb 26 2016

Keywords

  • cardiac troponin I
  • colorimetric
  • detection
  • electrochemical
  • fluorescence
  • immunoassay
  • paramagnetic
  • surface plasmon resonance

ASJC Scopus subject areas

  • Bioengineering
  • Fluid Flow and Transfer Processes
  • Process Chemistry and Technology
  • Instrumentation

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