Recent applications of polymeric biomaterials and stem cells in tissue engineering and regenerative medicine

Sang Jin Lee, Janies J. Yoo, Anthony Atala

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

Tissue engineering and regenerative medicine strategies could offer new hope for patients with serious tissue injuries or end-stage organ failure. Scientists are now applying the principles of cell transplantation, material science, and engineering to create biological substitutes that can restore and maintain normal function in diseased or injured tissues/ organs. Specifically, creation of engineered tissue construct requires a polymeric biomaterial scaffold that serves as a cell carrier, which would provide structural support until native tissue forms in vivo. Even though the requirements for scaffolds may be different depending on the target applications, a general function of scaffolds that need to be fulfilled is bio-degradability, biological and mechanical properties, and temporal structural integrity. The scaffold's internal architecture should also enhance the permeability of nutrients and neovascularization. In addition, the stem cell field is advancing, and new discoveries in tissue engineering and regenerative medicine will lead to new therapeutic strategies. Although use of stem cells is still in the research phase, some therapies arising from tissue engineering endeavors that make use of autol-ogous adult cells have already entered the clinic. This review discusses these tissue engineering and regenerative medicine strategies for various tissues and organs.

Original languageEnglish (US)
Pages (from-to)113-128
Number of pages16
JournalPolymer (Korea)
Volume38
Issue number2
DOIs
StatePublished - Mar 2014

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Keywords

  • Biomaterials
  • Extracellular matrix
  • Polymers
  • Regenerative medicine
  • Stem cells
  • Tissue engineering

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Materials Chemistry
  • Polymers and Plastics

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