Recent advances in understanding the pathogenesis of cardiovascular diseases and development of treatment modalities

Rahul Mittal, Vasanti M. Jhaveri, Sae In Samantha Kay, Aubrey Greer, Kyle J. Sutherland, Hannah S. McMurry, Nicole Lin, Jeenu Mittal, Arul K. Malhotra, Amit P. Patel

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Cardiovascular Diseases (CVDs) are a leading cause of morbidity and mortality worldwide. The underlying pathology for cardiovascular disease is largely atherosclerotic in nature and the steps include fatty streak formation, plaque progression and plaque rupture. While there is optimal drug therapy available for patients with CVD, there are also underlying drug delivery obstacles that must be addressed. Challenges in drug delivery warrant further studies for the development of novel and more efficacious medical therapies. An extensive understanding of the molecular mechanisms of disease in combination with current challenges in drug delivery serves as a platform for the development of novel drug therapeutic targets for CVD. The objective of this article is to review the pathogenesis of atherosclerosis, first-line medical treatment for CVD, and key obstacles in an efficient drug delivery.

Original languageEnglish (US)
Pages (from-to)19-32
Number of pages14
JournalCardiovascular and Hematological Disorders - Drug Targets
Volume19
Issue number1
DOIs
StatePublished - 2019

Keywords

  • Atherosclerosis
  • Cardiovascular diseases
  • Drug delivery
  • Fatty streak formation
  • Plaque progression
  • Treatment modalities

ASJC Scopus subject areas

  • Molecular Medicine
  • Hematology
  • Pharmacology
  • Cardiology and Cardiovascular Medicine

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