Recent advances in the genetics of testicular failure

Seung Hun Song, Koji Chiba, Ranjith Ramasamy, Dolores J. Lamb

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Infertility affects approximately 15% of couples, and male factor is responsible for 30%-50% of all infertility. The most severe form of male infertility is testicular failure, and the typical phenotype of testicular failure is severely impaired spermatogenesis resulting in azoospermia or severe oligozoospermia. Although the etiology of testicular failure remains poorly understood, genetic factor typically is an underlying cause. Modern assisted reproductive techniques have revolutionized the treatment of male factor infertility, allowing biological fatherhood to be achieved by many men who would otherwise have been unable to become father to their children through natural conception. Therefore, identifying genetic abnormalities in male is critical because of the potential risk of transmission of genetic abnormalities to the offspring. Recently, along with other intense researches ongoing, whole-genome approaches have been used increasingly in the genetic studies of male infertility. In this review, we focus on the genetics of testicular failure and provide an update on the advances in the study of genetics of male infertility.

Original languageEnglish (US)
Pages (from-to)350-355
Number of pages6
JournalAsian Journal of Andrology
Volume18
Issue number3
DOIs
StatePublished - May 1 2016

Fingerprint

Male Infertility
Infertility
Oligospermia
Azoospermia
Assisted Reproductive Techniques
Spermatogenesis
Fathers
Genome
Phenotype
Research
Therapeutics

Keywords

  • azoospermia
  • genetics
  • male infertility
  • testicular failure

ASJC Scopus subject areas

  • Urology

Cite this

Recent advances in the genetics of testicular failure. / Song, Seung Hun; Chiba, Koji; Ramasamy, Ranjith; Lamb, Dolores J.

In: Asian Journal of Andrology, Vol. 18, No. 3, 01.05.2016, p. 350-355.

Research output: Contribution to journalArticle

Song, Seung Hun ; Chiba, Koji ; Ramasamy, Ranjith ; Lamb, Dolores J. / Recent advances in the genetics of testicular failure. In: Asian Journal of Andrology. 2016 ; Vol. 18, No. 3. pp. 350-355.
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