Recent advances in retrovirus vector-mediated gene therapy: Teaching an old vector new tricks

E. Weber, W. French Anderson, N. Kasahara

Research output: Contribution to journalReview article

41 Scopus citations

Abstract

Oncoretrovirus-based vectors have been shown to be a safe and reliable vector system that can achieve permanent integration of delivered transgenes. Successful application of these vectors for gene therapy has proven difficult due to their relatively low transduction efficiency; however, cumulative improvements in methodology have recently yielded promising clinical results. Furthermore, significant improvements in basic retrovirus vector technology now promise to revitalize the field. This review focuses on these important recent developments in the field of retrovirus-mediated gene transfer technology and its application to human diseases.

Original languageEnglish (US)
Pages (from-to)439-453
Number of pages15
JournalCurrent Opinion in Molecular Therapeutics
Volume3
Issue number5
StatePublished - 2001

Keywords

  • Embryonic stem cells
  • Gene Therapy
  • Hematopoietic stem cells
  • MLV
  • Retrovirus
  • Vector

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Pharmacology
  • Drug Discovery
  • Genetics(clinical)

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