Recent advances in genome editing and creation of genetically modified pigs

James R. Butler, Joseph M. Ladowski, Gregory R. Martens, Matthew Tector, A. Joseph Tector

Research output: Contribution to journalReview articlepeer-review

41 Scopus citations


The field of xenotransplantation is benefiting greatly from recent advances in genetic engineering. The efficiency and pace with which new model animals are being created has dramatically sped progress towards clinical relevance. Endonuclease-driven genome editing now allows for the efficient generation of targeted genetic alterations. Herein we review the available methods of genetic engineering that have been successfully employed to create genetically modified pigs.

Original languageEnglish (US)
Pages (from-to)217-222
Number of pages6
JournalInternational Journal of Surgery
StatePublished - Nov 1 2015
Externally publishedYes


  • Endonuclease
  • Homologous recombination
  • Off-target
  • Zinc finger nuclease

ASJC Scopus subject areas

  • Surgery


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