Recent advances in detection of human T-cell leukemia viruses type I type II infection

J. D. Rosenblatt, J. A. Zack, I. S.Y. Chen, H. Lee

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The human T-cell leukemia viruses type I(HTLV-I) and type II (HTLV-II) have been implicated in the pathogenesis of a variety of neoplastic and neurological disorders. Classical techniques for detection involve assay of serum for antibodies by Western blotting or ELISA, which do not discriminate between infection with HTLV-I and HTLV-II. In order to provide appropriate prognostic information to infected individuals and to obtain an accurate assessment of the prevalence of both retroviruses in the United States, we and others have applied the technique of enzymatic DNA amplification to detect HTLV-I and HTLV-II. These techniques allow rapid detection of viral nucleic acids in freshly isolated peripheral blood samples. Recent studies indicate an unusually high rate of HTLV-II infection among seropositive individuals in a sampling of New Orleans intravenous drug users, indicating a need for combined serological and molecular genetic screening of high-risk populations.

Original languageEnglish (US)
Pages (from-to)143-149
Number of pages7
JournalNatural Immunity and Cell Growth Regulation
Volume9
Issue number3
StatePublished - Oct 5 1990
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology
  • Clinical Biochemistry

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