Recent advances and current challenges in tumor immunology and immunotherapy

Barbara Ann Guinn, Noriyuki Kasahara, Farzin Farzaneh, Nagy A. Habib, James S. Norris, Albert B. Deisseroth

Research output: Contribution to journalReview article

28 Scopus citations

Abstract

Despite advances in animal studies, where the cure of the majority of mice with pre-established (albeit early-stage) tumors has become almost standard, human clinical trials have been much less successful. Here we describe some of the most recent advances in the specialist field of tumor immunology and immunotherapy, highlighting salient work to identify key problem areas and potential solutions. We make particular note of recent developments in adoptive therapy; whole-cell, DNA, and peptide vaccines; and antibody therapy. We also describe the revival of interest in regulatory T cells and conclude by detailing the need for clinical trial read-out autonomy and methods to predict which patients will respond to a particular treatment.

Original languageEnglish (US)
Pages (from-to)1065-1071
Number of pages7
JournalMolecular Therapy
Volume15
Issue number6
DOIs
StatePublished - Jun 1 2007
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Pharmacology
  • Drug Discovery

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  • Cite this

    Guinn, B. A., Kasahara, N., Farzaneh, F., Habib, N. A., Norris, J. S., & Deisseroth, A. B. (2007). Recent advances and current challenges in tumor immunology and immunotherapy. Molecular Therapy, 15(6), 1065-1071. https://doi.org/10.1038/sj.mt.6300138