Recent Advancements in Gene and Stem Cell-Based Treatment Modalities: Potential Implications in Noise-Induced Hearing Loss

Adrien Eshraghi, Hyunseo D. Jung, Rahul Mittal

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Noise-induced hearing loss (NIHL) poses a significant burden on not only the economics of health care but also the quality of life of an individual, as we approach an unprecedented age of longevity. In this article, we will delineate the current landscape of management of NIHL. We discuss the most recent results from in vitro and in vivo studies that determine the effectiveness of established pharmacotherapy such as corticosteroid and potential emerging therapies like N-acetyl cysteine and neurotrophins (NTs), as well as highlight ongoing clinical trials for these therapeutic agents. We present an overview of how the recent advancements in the field of gene-based and stem cell-based therapies can help in developing effective therapeutic strategies for NIHL. Gene-based therapies have shown exciting results demonstrating cochlear cellular regeneration using Atoh1, NRF2 as well as NT gene therapy employing viral vectors. In addition, we will discuss the recent advancements in genome-editing technologies, such as CRISPR/Cas9, and its potential role in NIHL therapy. We will further discuss the current state of stem cell therapy as it pertains to treating neurodegenerative conditions including NIHL. Embryonic stem cells, adult-derived stem cells, and induced pluripotent stem cells all represent an enticing reservoir of replacing damaged cells as a result of NIHL. Finally, we will discuss the barriers that need to be overcome to translate these promising treatment modalities to the clinical practice in pursuit of improving quality of life of patients having NIHL. Anat Rec, 2019.

Original languageEnglish (US)
JournalAnatomical Record
DOIs
StatePublished - Jan 1 2019

Fingerprint

Noise-Induced Hearing Loss
hearing
stem cells
Stem Cells
stem
therapeutics
gene
Genes
genes
neurotrophins
Nerve Growth Factors
Cell- and Tissue-Based Therapy
quality of life
Genetic Therapy
Therapeutics
Clustered Regularly Interspaced Short Palindromic Repeats
Quality of Life
Induced Pluripotent Stem Cells
acetylcysteine
Adult Stem Cells

Keywords

  • CRISPR/Cas9
  • gene therapy
  • inner ear
  • noise-induced hearing loss
  • stem-cell based therapy

ASJC Scopus subject areas

  • Anatomy
  • Biotechnology
  • Histology
  • Ecology, Evolution, Behavior and Systematics

Cite this

Recent Advancements in Gene and Stem Cell-Based Treatment Modalities : Potential Implications in Noise-Induced Hearing Loss. / Eshraghi, Adrien; Jung, Hyunseo D.; Mittal, Rahul.

In: Anatomical Record, 01.01.2019.

Research output: Contribution to journalArticle

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