Real-World Study on Sofosbuvir-based Therapies in Asian Americans with Chronic Hepatitis C

Calvin Q. Pan, Benjamin C. Tiongson, Ke Qin Hu, Steven Huy B. Han, Myron Tong, Danny Chu, James Park, Tai Ping Lee, Kalyan Ram Bhamidimarri, Xiaoli Ma, Pei Ying Xiao, Smruti R. Mohanty, Dan Wang

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1 Scopus citations

Abstract

Background: Limited data exist with regard to treatment outcomes in Asian Americans with chronic hepatitis C (CHC). We evaluated sofosbuvir (SOF)-based regimens in a national cohort of Asian Americans. Methods: Eligible Asian Americans patients with CHC who had posttreatment follow-up of 24 weeks for SOF-based therapies from December 2013 to June 2017 were enrolled from 11 sites across the United States. The primary endpoint was sustained virologic response (SVR) rates at posttreatment weeks 12 and 24. Secondary endpoints were to evaluate safety by tolerability and adverse events (AEs). Results: Among 231 patients screened, 186 were enrolled. At baseline, 31% (57/186) patients were cirrhotic, 34% (63/186) were treatment experienced. Most of the subjects (42%, 79/186) received ledispavir/SOF therapy. The overall SVR12 was 95%, ranging from 86% in genotype (GT) 1b on SOF+ribavirin to 100% in GT 1b patients on ledipasvir/SOF at subgroup analyses. SVR12 was significantly lower in cirrhotic than in noncirrhotic patients [88% (50/57) vs. 98% (126/129), P<0.01]. Stratified by GT, SVR12 were: 96% (43/45) in GT 1a; 93% (67/72) in GT 1b; 100% (23/23) in GT 2; 90% (19/21) in GT 3; 100% (1/1) in GT 4; 83% (5/6) in GT 5; and 100% (16/16) in GT 6. Cirrhotic patients with treatment failure were primarily GT 1, (GT 1a, n=2; GT 1b, n=4) with 1 GT 5 (n=1). Patients tolerated the treatment without serious AEs. Late relapse occurred in 1 patient after achieving SVR12. Conclusions: In Asian Americans with CHC, SOF-based regimens were well tolerated without serious AEs and could achieve high SVR12 regardless of hepatitis C viral infection GT.

Original languageEnglish (US)
Pages (from-to)147-154
Number of pages8
JournalJournal of clinical gastroenterology
Volume53
Issue number2
DOIs
StatePublished - Feb 1 2019

Keywords

  • Asian Americans
  • direct-acting antivirals
  • hepatits C
  • sustained viral response

ASJC Scopus subject areas

  • Gastroenterology

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    Pan, C. Q., Tiongson, B. C., Hu, K. Q., Han, S. H. B., Tong, M., Chu, D., Park, J., Lee, T. P., Bhamidimarri, K. R., Ma, X., Xiao, P. Y., Mohanty, S. R., & Wang, D. (2019). Real-World Study on Sofosbuvir-based Therapies in Asian Americans with Chronic Hepatitis C. Journal of clinical gastroenterology, 53(2), 147-154. https://doi.org/10.1097/MCG.0000000000001078