Real time magnetic resonance guided endomyocardial local delivery

R. Corti, J. Badimon, G. Mizsei, F. Macaluso, M. Lee, P. Licato, Juan Viles Gonzalez, V. Fuster, Warren Sherman

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Objective: To investigate the feasibility of targeting various areas of left ventricle myocardium under real time magnetic resonance (MR) imaging with a customised injection catheter equipped with a miniaturised coil. Design: A needle injection catheter with a mounted resonant solenoid circuit (coil) at its tip was designed and constructed. A 1.5 T MR scanner with customised real time sequence combined with in-room scan running capabilities was used. With this system, various myocardial areas within the left ventricle were targeted and injected with a gadolinium-diethylenetriaminepentaacetic acid (DTPA) and Indian ink mixture. Results: Real time sequencing at 10 frames/s allowed clear visualisation of the moving catheter and its transit through the aorta into the ventricle, as well as targeting of all ventricle wall segments without further image enhancement techniques. All injections were visualised by real time MR imaging and verified by gross pathology. Conclusion: The tracking device allowed real time in vivo visualisation of catheters in the aorta and left ventricle as well as precise targeting of myocardial areas. The use of this real time catheter tracking may enable precise and adequate delivery of agents for tissue regeneration.

Original languageEnglish
Pages (from-to)348-353
Number of pages6
JournalHeart
Volume91
Issue number3
DOIs
StatePublished - Mar 1 2005
Externally publishedYes

Fingerprint

Magnetic Resonance Spectroscopy
Catheters
Heart Ventricles
Injections
Aorta
Magnetic Resonance Imaging
Image Enhancement
Ink
Gadolinium
Needles
Regeneration
Myocardium
Pathology
Equipment and Supplies
Acids

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Corti, R., Badimon, J., Mizsei, G., Macaluso, F., Lee, M., Licato, P., ... Sherman, W. (2005). Real time magnetic resonance guided endomyocardial local delivery. Heart, 91(3), 348-353. https://doi.org/10.1136/hrt.2004.034363

Real time magnetic resonance guided endomyocardial local delivery. / Corti, R.; Badimon, J.; Mizsei, G.; Macaluso, F.; Lee, M.; Licato, P.; Viles Gonzalez, Juan; Fuster, V.; Sherman, Warren.

In: Heart, Vol. 91, No. 3, 01.03.2005, p. 348-353.

Research output: Contribution to journalArticle

Corti, R, Badimon, J, Mizsei, G, Macaluso, F, Lee, M, Licato, P, Viles Gonzalez, J, Fuster, V & Sherman, W 2005, 'Real time magnetic resonance guided endomyocardial local delivery', Heart, vol. 91, no. 3, pp. 348-353. https://doi.org/10.1136/hrt.2004.034363
Corti R, Badimon J, Mizsei G, Macaluso F, Lee M, Licato P et al. Real time magnetic resonance guided endomyocardial local delivery. Heart. 2005 Mar 1;91(3):348-353. https://doi.org/10.1136/hrt.2004.034363
Corti, R. ; Badimon, J. ; Mizsei, G. ; Macaluso, F. ; Lee, M. ; Licato, P. ; Viles Gonzalez, Juan ; Fuster, V. ; Sherman, Warren. / Real time magnetic resonance guided endomyocardial local delivery. In: Heart. 2005 ; Vol. 91, No. 3. pp. 348-353.
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