Reactive oxygen species in vascular endothelial cell motility. Roles of NAD(P)H oxidase and Rac1

Leni Moldovan, Karthikeyan Mythreye, Pascal Goldschmidt-Clermont, Lisa L. Satterwhite

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

Reactive oxygen species (ROS) are acknowledged generally to be multi-faceted regulators of cellular functions that trigger various pathological states when present chronically or transiently at non-physiologically high levels. Here we focus on the physiological involvement of ROS in cellular motility, with special emphasis on endothelial cells (EC). An important source of ROS within EC is the non-phagocytic NAD(P)H oxidase, and the small GTPase Rac1 plays a central role in activating this complex. Rac1 is one of the three Rho-family molecules (Rac, Rho and Cdc42) involved in the control of the actin cytoskeleton in response to various signals. In this review we examine the evidence linking ROS production, Rac1 activation and actin organization to EC motility, considering mechanisms for direct interaction of ROS and actin and the effects of ROS on proteins that regulate the actin cytoskeleton. The accumulated evidence suggests that ROS are important regulators of the actin cytoskeletal dynamics and cellular motility, and more in-depth studies are needed to understand the underlying mechanisms.

Original languageEnglish
Pages (from-to)236-246
Number of pages11
JournalCardiovascular Research
Volume71
Issue number2
DOIs
StatePublished - Jul 15 2006

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NADPH Oxidase
Cell Movement
Reactive Oxygen Species
Endothelial Cells
Actins
Actin Cytoskeleton
Monomeric GTP-Binding Proteins
Proteins

Keywords

  • Cytoskeleton
  • Endothelial function
  • NADPH oxidase
  • Oxygen radicals
  • Redox signalling

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Reactive oxygen species in vascular endothelial cell motility. Roles of NAD(P)H oxidase and Rac1. / Moldovan, Leni; Mythreye, Karthikeyan; Goldschmidt-Clermont, Pascal; Satterwhite, Lisa L.

In: Cardiovascular Research, Vol. 71, No. 2, 15.07.2006, p. 236-246.

Research output: Contribution to journalArticle

Moldovan, Leni ; Mythreye, Karthikeyan ; Goldschmidt-Clermont, Pascal ; Satterwhite, Lisa L. / Reactive oxygen species in vascular endothelial cell motility. Roles of NAD(P)H oxidase and Rac1. In: Cardiovascular Research. 2006 ; Vol. 71, No. 2. pp. 236-246.
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