Re-evaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the Old Order Amish

J. R. Kelsoe, E. I. Ginns, Janice Egeland, D. S. Gerhard, A. M. Goldstein, S. J. Bale, D. L. Pauls, R. T. Long, K. K. Kidd, G. Conte, D. E. Housman, S. M. Paul

Research output: Contribution to journalArticle

317 Citations (Scopus)

Abstract

Reanalysis of an Old Order Amish pedigree, to include several new individuals and two changes in clinical status, markedly reduces the probability of linkage between bipolar affective disorder and the Harvey-ras-1 oncogene and insulin loci on chromosome 11. This linkage can be excluded using a large lateral extension of the original Amish pedigree.

Original languageEnglish
Pages (from-to)238-243
Number of pages6
JournalNature
Volume342
Issue number6247
StatePublished - Jan 1 1989

Fingerprint

Amish
Pedigree
Mood Disorders
Bipolar Disorder
Chromosomes
Chromosomes, Human, Pair 11
ras Genes
Genes
Insulin

ASJC Scopus subject areas

  • General

Cite this

Kelsoe, J. R., Ginns, E. I., Egeland, J., Gerhard, D. S., Goldstein, A. M., Bale, S. J., ... Paul, S. M. (1989). Re-evaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the Old Order Amish. Nature, 342(6247), 238-243.

Re-evaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the Old Order Amish. / Kelsoe, J. R.; Ginns, E. I.; Egeland, Janice; Gerhard, D. S.; Goldstein, A. M.; Bale, S. J.; Pauls, D. L.; Long, R. T.; Kidd, K. K.; Conte, G.; Housman, D. E.; Paul, S. M.

In: Nature, Vol. 342, No. 6247, 01.01.1989, p. 238-243.

Research output: Contribution to journalArticle

Kelsoe, JR, Ginns, EI, Egeland, J, Gerhard, DS, Goldstein, AM, Bale, SJ, Pauls, DL, Long, RT, Kidd, KK, Conte, G, Housman, DE & Paul, SM 1989, 'Re-evaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the Old Order Amish', Nature, vol. 342, no. 6247, pp. 238-243.
Kelsoe JR, Ginns EI, Egeland J, Gerhard DS, Goldstein AM, Bale SJ et al. Re-evaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the Old Order Amish. Nature. 1989 Jan 1;342(6247):238-243.
Kelsoe, J. R. ; Ginns, E. I. ; Egeland, Janice ; Gerhard, D. S. ; Goldstein, A. M. ; Bale, S. J. ; Pauls, D. L. ; Long, R. T. ; Kidd, K. K. ; Conte, G. ; Housman, D. E. ; Paul, S. M. / Re-evaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the Old Order Amish. In: Nature. 1989 ; Vol. 342, No. 6247. pp. 238-243.
@article{fc7c49120aa843ecbd41186ef6b9bb18,
title = "Re-evaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the Old Order Amish",
abstract = "Reanalysis of an Old Order Amish pedigree, to include several new individuals and two changes in clinical status, markedly reduces the probability of linkage between bipolar affective disorder and the Harvey-ras-1 oncogene and insulin loci on chromosome 11. This linkage can be excluded using a large lateral extension of the original Amish pedigree.",
author = "Kelsoe, {J. R.} and Ginns, {E. I.} and Janice Egeland and Gerhard, {D. S.} and Goldstein, {A. M.} and Bale, {S. J.} and Pauls, {D. L.} and Long, {R. T.} and Kidd, {K. K.} and G. Conte and Housman, {D. E.} and Paul, {S. M.}",
year = "1989",
month = "1",
day = "1",
language = "English",
volume = "342",
pages = "238--243",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "6247",

}

TY - JOUR

T1 - Re-evaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the Old Order Amish

AU - Kelsoe, J. R.

AU - Ginns, E. I.

AU - Egeland, Janice

AU - Gerhard, D. S.

AU - Goldstein, A. M.

AU - Bale, S. J.

AU - Pauls, D. L.

AU - Long, R. T.

AU - Kidd, K. K.

AU - Conte, G.

AU - Housman, D. E.

AU - Paul, S. M.

PY - 1989/1/1

Y1 - 1989/1/1

N2 - Reanalysis of an Old Order Amish pedigree, to include several new individuals and two changes in clinical status, markedly reduces the probability of linkage between bipolar affective disorder and the Harvey-ras-1 oncogene and insulin loci on chromosome 11. This linkage can be excluded using a large lateral extension of the original Amish pedigree.

AB - Reanalysis of an Old Order Amish pedigree, to include several new individuals and two changes in clinical status, markedly reduces the probability of linkage between bipolar affective disorder and the Harvey-ras-1 oncogene and insulin loci on chromosome 11. This linkage can be excluded using a large lateral extension of the original Amish pedigree.

UR - http://www.scopus.com/inward/record.url?scp=0024437794&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024437794&partnerID=8YFLogxK

M3 - Article

C2 - 2682265

AN - SCOPUS:0024437794

VL - 342

SP - 238

EP - 243

JO - Nature

JF - Nature

SN - 0028-0836

IS - 6247

ER -