Re-engineering islet cell transplantation

Nicoletta Fotino, Carmen Fotino, Antonello Pileggi

Research output: Contribution to journalReview article

23 Scopus citations

Abstract

We are living exciting times in the field of beta cell replacement therapies for the treatment of diabetes. While steady progress has been recorded thus far in clinical islet transplantation, novel approaches are needed to make cell-based therapies more reproducible and leading to long-lasting success. The multiple facets of diabetes impose the need for a transdisciplinary approach to attain this goal, by targeting immunity, promoting engraftment and sustained functional potency. We discuss herein the emerging technologies applied to this rapidly evolving field.

Original languageEnglish (US)
Pages (from-to)76-85
Number of pages10
JournalPharmacological Research
Volume98
DOIs
StatePublished - Jun 12 2015

Keywords

  • Beta cells
  • Biomaterials
  • Cellular therapies
  • Diabetes
  • Implantable devices
  • Insulin
  • Islet transplantation
  • Islets of Langerhans
  • Stem cells
  • Tissue engineering

ASJC Scopus subject areas

  • Pharmacology

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