Re-engineering islet cell transplantation

Nicoletta Fotino, Carmen Fotino, Antonello Pileggi

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

We are living exciting times in the field of beta cell replacement therapies for the treatment of diabetes. While steady progress has been recorded thus far in clinical islet transplantation, novel approaches are needed to make cell-based therapies more reproducible and leading to long-lasting success. The multiple facets of diabetes impose the need for a transdisciplinary approach to attain this goal, by targeting immunity, promoting engraftment and sustained functional potency. We discuss herein the emerging technologies applied to this rapidly evolving field.

Original languageEnglish (US)
Pages (from-to)76-85
Number of pages10
JournalPharmacological Research
Volume98
DOIs
StatePublished - Feb 6 2015
Externally publishedYes

Fingerprint

Islets of Langerhans Transplantation
Cell Transplantation
Cell- and Tissue-Based Therapy
Islets of Langerhans
Immunity
Technology
Therapeutics

Keywords

  • Beta cells
  • Biomaterials
  • Cellular therapies
  • Diabetes
  • Implantable devices
  • Insulin
  • Islet transplantation
  • Islets of Langerhans
  • Stem cells
  • Tissue engineering

ASJC Scopus subject areas

  • Pharmacology

Cite this

Re-engineering islet cell transplantation. / Fotino, Nicoletta; Fotino, Carmen; Pileggi, Antonello.

In: Pharmacological Research, Vol. 98, 06.02.2015, p. 76-85.

Research output: Contribution to journalArticle

Fotino, Nicoletta ; Fotino, Carmen ; Pileggi, Antonello. / Re-engineering islet cell transplantation. In: Pharmacological Research. 2015 ; Vol. 98. pp. 76-85.
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