Abstract
Breast cancer is second only to lung cancer as a leading cause of cancer mortality in women. In women with metastatic, hence, essentially incurable disease, we strive to find effective chemotherapeutic regimens that offer a higher quality of life free of the many toxicities associated with standard therapies. We have treated a small group of patients who were heavily pretreated for metastatic breast cancer with pegylated liposomal doxorubicin (PEG-LD) (Doxil) and demonstrated clinical benefit without the usual concomitant toxicity of traditional doxorubicin (Adriamycin). We have initiated trials of combination chemotherapy with PEG-LD with agents designed to improve clinical efficacy, while maintaining or improving patients' quality of life. We believe that optimal schedules for use of PEG-LD, and its combination with other agents, will provide promising options for treating patients with metastatic breast cancer.
Original language | English (US) |
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Pages (from-to) | 45-53 |
Number of pages | 9 |
Journal | ONCOLOGY |
Volume | 11 |
Issue number | 10 SUPPL. 12 |
State | Published - Dec 1 1997 |
ASJC Scopus subject areas
- Oncology
- Cancer Research