Rates of decompensation, hepatocellular carcinoma and mortality in AMA-negative primary biliary cholangitis cirrhosis

Binu V. John, Bassam Dahman, Yangyang Deng, Nidah S. Khakoo, Tamar H. Taddei, David E. Kaplan, Cynthia Levy

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The natural history of patients with anti-mitochondrial antibody (AMA)-negative Primary Biliary Cholangitis (PBC) cirrhosis has not been well defined, with prior studies showing discordant results. Furthermore, most studies of AMA-negative PBC have limited numbers of patients with cirrhosis and liver-related outcomes. Methods: We investigated the association of AMA-negative PBC and the development of death, liver-related death, decompensation and hepatocellular carcinoma (HCC), in a large cohort of predominantly male patients with PBC cirrhosis assembled from the Veterans Health Administration. Results: In a cohort of 521 patients with PBC cirrhosis (65 AMA-negative) with a total follow-up of 2504.3 person-years (PY) from cirrhosis diagnosis, patients with AMA-negative PBC were younger and more likely to be black but had similar rates of UDCA response. AMA-negative PBC cirrhosis was associated with similar unadjusted rates of liver-related death (4.6 vs 5.9 per 100 PY, P =.44), overall death (7.7 vs 9.6 per 100 PY, P =.31), decompensation (7.3 vs 5.1 per 100 PY, P =.12) and HCC (0.6 vs 1.0 per 100 PY, P =.63) to AMA-positive PBC. After adjusting for confounders, AMA-negative PBC cirrhosis was associated with similar rates of liver-related death (sub-Hazard Ratio [sHR] 1.27, 95% CI 0.71-2.28, P =.42, death [sHR] 1.24, 95% CI 0.81-1.90, P =.32), decompensation (sHR 1.05, 95% CI 0.56-1.98, P =.87) and HCC (sHR 0.48, 95% CI 0.11-2.10, P =.33) to AMA-positive patients. Conclusion: In a cohort of predominantly male patients, AMA-negative PBC cirrhosis was associated with similar rates of overall or liver-related death, HCC or decompensation compared with AMA-positive disease.

Original languageEnglish (US)
JournalLiver International
DOIs
StateAccepted/In press - 2021

Keywords

  • antimitochondrial antibodies
  • autoimmune liver disease
  • cholestatic liver disease
  • decompensation
  • hepatocellular carcinoma
  • primary biliary cholangitis

ASJC Scopus subject areas

  • Hepatology

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