Rate of AIDS progression is associated with gastrointestinal dysfunction in simian immunodeficiency virus-infected pigtail macaques

Lauren A. Canary, Carol L. Vinton, David R. Morcock, Jordan B. Pierce, Jacob D. Estes, Jason M. Brenchley, Nichole Klatt

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

During HIV/SIV infection, mucosal immune system dysfunction and systemic immune activation are associated with progression to AIDS; however, it is unclear to what extent pre-existing gastrointestinal damage relates to disease progression postinfection. Pigtail macaques (PTM) are an excellent model in which to assess mucosal dysfunction in relation to HIV/SIV pathogenesis, as the majority of these animals have high levels of gastrointestinal damage, immune activation, and microbial translocation prior to infection, and rapidly progress to AIDS upon SIV infection. In this study, we characterized the mucosal immune environment prior to and throughout SIV infection in 13 uninfected PTM and 9 SIV-infected PTM, of which 3 were slow progressors. This small subset of slow progressors had limited innate immune activation in mucosal tissues in the periphery, which was associated with a more intact colonic epithelial barrier. Furthermore, we found that preinfection levels of microbial translocation, as measured by LPSbinding protein, in PTM correlated with the rate of progression to AIDS. These data suggest that pre-existing levels of microbial translocation and gastrointestinal tract dysfunction may influence the rate of HIV disease progression.

Original languageEnglish (US)
Pages (from-to)2959-2965
Number of pages7
JournalJournal of Immunology
Volume190
Issue number6
DOIs
StatePublished - Mar 15 2013
Externally publishedYes

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Macaca nemestrina
Simian Immunodeficiency Virus
Acquired Immunodeficiency Syndrome
Disease Progression
Infection
HIV
HIV Infections
Gastrointestinal Tract
Immune System
Mucous Membrane
Proteins

ASJC Scopus subject areas

  • Immunology

Cite this

Rate of AIDS progression is associated with gastrointestinal dysfunction in simian immunodeficiency virus-infected pigtail macaques. / Canary, Lauren A.; Vinton, Carol L.; Morcock, David R.; Pierce, Jordan B.; Estes, Jacob D.; Brenchley, Jason M.; Klatt, Nichole.

In: Journal of Immunology, Vol. 190, No. 6, 15.03.2013, p. 2959-2965.

Research output: Contribution to journalArticle

Canary, Lauren A. ; Vinton, Carol L. ; Morcock, David R. ; Pierce, Jordan B. ; Estes, Jacob D. ; Brenchley, Jason M. ; Klatt, Nichole. / Rate of AIDS progression is associated with gastrointestinal dysfunction in simian immunodeficiency virus-infected pigtail macaques. In: Journal of Immunology. 2013 ; Vol. 190, No. 6. pp. 2959-2965.
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