Abstract
The purpose of this study was to see how the nominal removal of bicarbonate (HCO3/-) from the extracellular space of brain tissue influenced recovery of brain tissue from anoxia. Removal of HCO3/- in HEPES-buffered artificial cerebrospinal fluid (aCSF) inhibited almost completely recovery of synaptic transmission in hippocampal slices after anoxia. Altered pH did not contribute to this finding because adjusting intracellular (pH(i)) and extracellular (pH(o)) pH to control levels did not reduce the effect of HCO3/- removal. Our results suggest that HCO3/- levels are important in determining the extent of anoxic or ischemic brain injury. (C) 2000 Elsevier Science B.V.
Original language | English (US) |
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Pages (from-to) | 171-174 |
Number of pages | 4 |
Journal | Brain research |
Volume | 875 |
Issue number | 1-2 |
DOIs | |
State | Published - Sep 1 2000 |
Keywords
- Acidosis
- CA1
- Carboxy-SNARF-1
- Extracellular pH
- HEPES
- Intracellular pH
ASJC Scopus subject areas
- Neuroscience(all)