Rare variant APOC3 R19X is associated with cardio-protective profiles in a diverse population-based survey as part of the epidemiologic architecture for genes linked to environment study

Dana C. Crawford, Logan Dumitrescu, Robert Goodloe, Kristin Brown-Gentry, Jonathan Boston, Bob McClellan, Cara Sutcliffe, Rachel Wiseman, Paxton Baker, Margaret A Pericak-Vance, William K Scott, Melissa Allen, Ping Mayo, Nathalie Schnetz-Boutaud, Holli H. Dilks, Jonathan L. Haines, Toni I. Pollin

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background-A founder mutation was recently discovered and described as conferring favorable lipid profiles and reduced subclinical atherosclerotic disease in a Pennsylvania Amish population. Preliminary data have suggested that this null mutation APOC3 R19X (rs76353203) is rare in the general population. Methods and Results-To better describe the frequency and lipid profile in the general population, we as part of the Population Architecture using Genomics and Epidemiology I Study and the Epidemiological Architecture for Genes Linked to Environment Study genotyped rs76353203 in 1113 Amish participants from Ohio and Indiana and 19 613 participants from the National Health and Nutrition Examination Surveys (NHANES III, 1999 to 2002, and 2007 to 2008). We found no carriers among the Ohio and Indiana Amish. Of the 19 613 NHANES participants, we identified 31 participants carrying the 19X allele, for an overall allele frequency of 0.08%. Among fasting adults, the 19X allele was associated with lower triglycerides (n=7603; β=-71.20; P=0.007) and higher high-density lipoprotein cholesterol (n=8891; β=15.65; P=0.0002) and, although not significant, lower low-density lipoprotein cholesterol (n=6502; β= -4.85; P=0.68) after adjustment for age, sex, and race/ethnicity. On average, 19X allele participants had approximately half the triglyceride levels (geometric means, 51.3 to 69.7 versus 134.6 to 141.3 mg/dL), >20% higher high-density lipoprotein cholesterol levels (geometric means, 56.8 to 74.4 versus 50.38 to 53.36 mg/dL), and lower low-density lipoprotein cholesterol levels (geometric means, 104.5 to 128.6 versus 116.1 to 125.7 mg/dL) compared with noncarrier participants. Conclusions-These data demonstrate that APOC3 19X exists in the general US population in multiple racial/ethnic groups and is associated with cardio-protective lipid profiles.

Original languageEnglish (US)
Pages (from-to)848-853
Number of pages6
JournalCirculation: Cardiovascular Genetics
Volume7
Issue number6
DOIs
StatePublished - Dec 1 2014

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Amish
Nutrition Surveys
Population
Genes
Alleles
Lipids
LDL Cholesterol
HDL Cholesterol
Triglycerides
Mutation
Genomics
Ethnic Groups
Gene Frequency
Epidemiologic Studies
Fasting
Epidemiology
Surveys and Questionnaires

Keywords

  • Genetic association studies
  • Genetics
  • High-density lipoprotein cholesterol
  • Molecular epidemiology
  • Triglycerides

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Genetics(clinical)
  • Genetics

Cite this

Rare variant APOC3 R19X is associated with cardio-protective profiles in a diverse population-based survey as part of the epidemiologic architecture for genes linked to environment study. / Crawford, Dana C.; Dumitrescu, Logan; Goodloe, Robert; Brown-Gentry, Kristin; Boston, Jonathan; McClellan, Bob; Sutcliffe, Cara; Wiseman, Rachel; Baker, Paxton; Pericak-Vance, Margaret A; Scott, William K; Allen, Melissa; Mayo, Ping; Schnetz-Boutaud, Nathalie; Dilks, Holli H.; Haines, Jonathan L.; Pollin, Toni I.

In: Circulation: Cardiovascular Genetics, Vol. 7, No. 6, 01.12.2014, p. 848-853.

Research output: Contribution to journalArticle

Crawford, DC, Dumitrescu, L, Goodloe, R, Brown-Gentry, K, Boston, J, McClellan, B, Sutcliffe, C, Wiseman, R, Baker, P, Pericak-Vance, MA, Scott, WK, Allen, M, Mayo, P, Schnetz-Boutaud, N, Dilks, HH, Haines, JL & Pollin, TI 2014, 'Rare variant APOC3 R19X is associated with cardio-protective profiles in a diverse population-based survey as part of the epidemiologic architecture for genes linked to environment study', Circulation: Cardiovascular Genetics, vol. 7, no. 6, pp. 848-853. https://doi.org/10.1161/CIRCGENETICS.113.000369
Crawford, Dana C. ; Dumitrescu, Logan ; Goodloe, Robert ; Brown-Gentry, Kristin ; Boston, Jonathan ; McClellan, Bob ; Sutcliffe, Cara ; Wiseman, Rachel ; Baker, Paxton ; Pericak-Vance, Margaret A ; Scott, William K ; Allen, Melissa ; Mayo, Ping ; Schnetz-Boutaud, Nathalie ; Dilks, Holli H. ; Haines, Jonathan L. ; Pollin, Toni I. / Rare variant APOC3 R19X is associated with cardio-protective profiles in a diverse population-based survey as part of the epidemiologic architecture for genes linked to environment study. In: Circulation: Cardiovascular Genetics. 2014 ; Vol. 7, No. 6. pp. 848-853.
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abstract = "Background-A founder mutation was recently discovered and described as conferring favorable lipid profiles and reduced subclinical atherosclerotic disease in a Pennsylvania Amish population. Preliminary data have suggested that this null mutation APOC3 R19X (rs76353203) is rare in the general population. Methods and Results-To better describe the frequency and lipid profile in the general population, we as part of the Population Architecture using Genomics and Epidemiology I Study and the Epidemiological Architecture for Genes Linked to Environment Study genotyped rs76353203 in 1113 Amish participants from Ohio and Indiana and 19 613 participants from the National Health and Nutrition Examination Surveys (NHANES III, 1999 to 2002, and 2007 to 2008). We found no carriers among the Ohio and Indiana Amish. Of the 19 613 NHANES participants, we identified 31 participants carrying the 19X allele, for an overall allele frequency of 0.08{\%}. Among fasting adults, the 19X allele was associated with lower triglycerides (n=7603; β=-71.20; P=0.007) and higher high-density lipoprotein cholesterol (n=8891; β=15.65; P=0.0002) and, although not significant, lower low-density lipoprotein cholesterol (n=6502; β= -4.85; P=0.68) after adjustment for age, sex, and race/ethnicity. On average, 19X allele participants had approximately half the triglyceride levels (geometric means, 51.3 to 69.7 versus 134.6 to 141.3 mg/dL), >20{\%} higher high-density lipoprotein cholesterol levels (geometric means, 56.8 to 74.4 versus 50.38 to 53.36 mg/dL), and lower low-density lipoprotein cholesterol levels (geometric means, 104.5 to 128.6 versus 116.1 to 125.7 mg/dL) compared with noncarrier participants. Conclusions-These data demonstrate that APOC3 19X exists in the general US population in multiple racial/ethnic groups and is associated with cardio-protective lipid profiles.",
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AU - Dumitrescu, Logan

AU - Goodloe, Robert

AU - Brown-Gentry, Kristin

AU - Boston, Jonathan

AU - McClellan, Bob

AU - Sutcliffe, Cara

AU - Wiseman, Rachel

AU - Baker, Paxton

AU - Pericak-Vance, Margaret A

AU - Scott, William K

AU - Allen, Melissa

AU - Mayo, Ping

AU - Schnetz-Boutaud, Nathalie

AU - Dilks, Holli H.

AU - Haines, Jonathan L.

AU - Pollin, Toni I.

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N2 - Background-A founder mutation was recently discovered and described as conferring favorable lipid profiles and reduced subclinical atherosclerotic disease in a Pennsylvania Amish population. Preliminary data have suggested that this null mutation APOC3 R19X (rs76353203) is rare in the general population. Methods and Results-To better describe the frequency and lipid profile in the general population, we as part of the Population Architecture using Genomics and Epidemiology I Study and the Epidemiological Architecture for Genes Linked to Environment Study genotyped rs76353203 in 1113 Amish participants from Ohio and Indiana and 19 613 participants from the National Health and Nutrition Examination Surveys (NHANES III, 1999 to 2002, and 2007 to 2008). We found no carriers among the Ohio and Indiana Amish. Of the 19 613 NHANES participants, we identified 31 participants carrying the 19X allele, for an overall allele frequency of 0.08%. Among fasting adults, the 19X allele was associated with lower triglycerides (n=7603; β=-71.20; P=0.007) and higher high-density lipoprotein cholesterol (n=8891; β=15.65; P=0.0002) and, although not significant, lower low-density lipoprotein cholesterol (n=6502; β= -4.85; P=0.68) after adjustment for age, sex, and race/ethnicity. On average, 19X allele participants had approximately half the triglyceride levels (geometric means, 51.3 to 69.7 versus 134.6 to 141.3 mg/dL), >20% higher high-density lipoprotein cholesterol levels (geometric means, 56.8 to 74.4 versus 50.38 to 53.36 mg/dL), and lower low-density lipoprotein cholesterol levels (geometric means, 104.5 to 128.6 versus 116.1 to 125.7 mg/dL) compared with noncarrier participants. Conclusions-These data demonstrate that APOC3 19X exists in the general US population in multiple racial/ethnic groups and is associated with cardio-protective lipid profiles.

AB - Background-A founder mutation was recently discovered and described as conferring favorable lipid profiles and reduced subclinical atherosclerotic disease in a Pennsylvania Amish population. Preliminary data have suggested that this null mutation APOC3 R19X (rs76353203) is rare in the general population. Methods and Results-To better describe the frequency and lipid profile in the general population, we as part of the Population Architecture using Genomics and Epidemiology I Study and the Epidemiological Architecture for Genes Linked to Environment Study genotyped rs76353203 in 1113 Amish participants from Ohio and Indiana and 19 613 participants from the National Health and Nutrition Examination Surveys (NHANES III, 1999 to 2002, and 2007 to 2008). We found no carriers among the Ohio and Indiana Amish. Of the 19 613 NHANES participants, we identified 31 participants carrying the 19X allele, for an overall allele frequency of 0.08%. Among fasting adults, the 19X allele was associated with lower triglycerides (n=7603; β=-71.20; P=0.007) and higher high-density lipoprotein cholesterol (n=8891; β=15.65; P=0.0002) and, although not significant, lower low-density lipoprotein cholesterol (n=6502; β= -4.85; P=0.68) after adjustment for age, sex, and race/ethnicity. On average, 19X allele participants had approximately half the triglyceride levels (geometric means, 51.3 to 69.7 versus 134.6 to 141.3 mg/dL), >20% higher high-density lipoprotein cholesterol levels (geometric means, 56.8 to 74.4 versus 50.38 to 53.36 mg/dL), and lower low-density lipoprotein cholesterol levels (geometric means, 104.5 to 128.6 versus 116.1 to 125.7 mg/dL) compared with noncarrier participants. Conclusions-These data demonstrate that APOC3 19X exists in the general US population in multiple racial/ethnic groups and is associated with cardio-protective lipid profiles.

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KW - High-density lipoprotein cholesterol

KW - Molecular epidemiology

KW - Triglycerides

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