RAR-β4, a retinoic acid receptor isoform is generated from RAR-β2 by alternative splicing and usage of a CUG initiator codon

S. Nagpal, Arthur Z Zelent, P. Chambon

Research output: Contribution to journalArticle

101 Citations (Scopus)

Abstract

An isoform of retinoic acid receptor β, RAR-β4, has been identified. RAR-β4 is expressed under the control of the same retinoic acid-responsive promoter as RAR-β2. RAR-β4, which is generated by alternative splicing from the same primary transcripts as RAR-β2, is initiated by a non-AUG codon, CUG. The amino acid sequence of RAR-β4 in regions B-F is identical to that of the other RAR-β isoforms β1, β2, and β3. However, the RAR-β4 A region is much shorter (4 amino acids long) than those of these isoforms. RAR-β4 exhibits a tissue-specific pattern of expression and distinct transcriptional activation properties when compared with the other RAR-β isoforms.

Original languageEnglish (US)
Pages (from-to)2718-2722
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume89
Issue number7
DOIs
StatePublished - Jan 1 1992
Externally publishedYes

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Retinoic Acid Receptors
Initiator Codon
Alternative Splicing
Protein Isoforms
Tretinoin
Codon
Transcriptional Activation
Amino Acid Sequence
Amino Acids

Keywords

  • development
  • non-AUG initiator codon
  • retinoic acid-inducible
  • specific expression

ASJC Scopus subject areas

  • General

Cite this

RAR-β4, a retinoic acid receptor isoform is generated from RAR-β2 by alternative splicing and usage of a CUG initiator codon. / Nagpal, S.; Zelent, Arthur Z; Chambon, P.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, No. 7, 01.01.1992, p. 2718-2722.

Research output: Contribution to journalArticle

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